1lrh: Difference between revisions
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[[Image:1lrh.gif|left|200px]] | [[Image:1lrh.gif|left|200px]] | ||
'''Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid''' | {{Structure | ||
|PDB= 1lrh |SIZE=350|CAPTION= <scene name='initialview01'>1lrh</scene>, resolution 1.9Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=NLA:NAPHTHALEN-1-YL-ACETIC ACID'>NLA</scene> | |||
|ACTIVITY= | |||
|GENE= ABP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4577 Zea mays]) | |||
}} | |||
'''Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1LRH is a [ | 1LRH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LRH OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of auxin-binding protein 1 in complex with auxin., Woo EJ, Marshall J, Bauly J, Chen JG, Venis M, Napier RM, Pickersgill RW, EMBO J. 2002 Jun 17;21(12):2877-85. PMID:[http:// | Crystal structure of auxin-binding protein 1 in complex with auxin., Woo EJ, Marshall J, Bauly J, Chen JG, Venis M, Napier RM, Pickersgill RW, EMBO J. 2002 Jun 17;21(12):2877-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12065401 12065401] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Zea mays]] | [[Category: Zea mays]] | ||
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[[Category: germin like protein]] | [[Category: germin like protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:34:15 2008'' | ||
Revision as of 10:34, 20 March 2008
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| 1lrh, resolution 1.9Å | |||||||||||||
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| Ligands: | ZN and NLA | ||||||||||||
| Gene: | ABP1 (Zea mays) | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of auxin-binding protein 1 in complex with 1-naphthalene acetic acid
Overview
The structure of auxin-binding protein 1 (ABP1) from maize has been determined at 1.9 A resolution, revealing its auxin-binding site. The structure confirms that ABP1 belongs to the ancient and functionally diverse germin/seed storage 7S protein superfamily. The binding pocket of ABP1 is predominantly hydrophobic with a metal ion deep inside the pocket coordinated by three histidines and a glutamate. Auxin binds within this pocket, with its carboxylate binding the zinc and its aromatic ring binding hydrophobic residues including Trp151. There is a single disulfide between Cys2 and Cys155. No conformational rearrangement of ABP1 was observed when auxin bound to the protein in the crystal, but examination of the structure reveals a possible mechanism of signal transduction.
About this Structure
1LRH is a Single protein structure of sequence from Zea mays. Full crystallographic information is available from OCA.
Reference
Crystal structure of auxin-binding protein 1 in complex with auxin., Woo EJ, Marshall J, Bauly J, Chen JG, Venis M, Napier RM, Pickersgill RW, EMBO J. 2002 Jun 17;21(12):2877-85. PMID:12065401
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