4rly: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Crystal Structure of AnkB Ankyrin Repeats (R1-R9) in Complex with Nav1.2 Ankyrin Binding Domain==

== Structural highlights ==

<table><tr><td colspan='2'>[[4rly]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RLY FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rlv|4rlv]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rly OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rly RCSB], [http://www.ebi.ac.uk/pdbsum/4rly PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Ankyrin adaptors together with their spectrin partners coordinate diverse ion channels and cell adhesion molecules within plasma membrane domains and thereby promote physiological activities including fast signaling in the heart and nervous system. Ankyrins specifically bind to numerous membrane targets through their 24 ankyrin repeats (ANK repeats), although the mechanism for the facile and independent evolution of these interactions has not been resolved. Here we report the structures of ANK repeats in complex with an inhibitory segment from the C-terminal regulatory domain and with a sodium channel Nav1.2 peptide, respectively, showing that the extended, extremely conserved inner groove spanning the entire ANK repeat solenoid contains multiple target binding sites capable of accommodating target proteins with very diverse sequences via combinatorial usage of these sites. These structures establish a framework for understanding the evolution of ankyrins' membrane targets, with implications for other proteins containing extended ANK repeat domains.

~~The entry 4rly is ON HOLD until Paper Publication~~

Structural basis of diverse membrane target recognitions by ankyrins.,Wang C, Wei Z, Chen K, Ye F, Yu C, Bennett V, Zhang M Elife. 2014 Nov 10;3. doi: 10.7554/eLife.04353. PMID:25383926<ref>PMID:25383926</ref>

~~Authors: Wei~~, Z., Wang, C., Zhang, M.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description~~: ~~Crystal Structure of AnkB Ankyrin Repeats (R1~~-~~R9) in Complex with Nav1.2 Ankyrin Binding Domain~~

== References ==

__TOC__

</StructureSection>

[[Category: Wang, C]]

[[Category: Wei, Z]]

[[Category: Zhang, M]]

[[Category: Ank repeat]]

[[Category: Protein-protein interaction]]

[[Category: Structural protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of AnkB Ankyrin Repeats (R1-R9) in Complex with Nav1.2 Ankyrin Binding Domain==
+<StructureSection load='4rly' size='340' side='right' caption='[[4rly]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rly]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RLY FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rlv|4rlv]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rly OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rly RCSB], [http://www.ebi.ac.uk/pdbsum/4rly PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Ankyrin adaptors together with their spectrin partners coordinate diverse ion channels and cell adhesion molecules within plasma membrane domains and thereby promote physiological activities including fast signaling in the heart and nervous system. Ankyrins specifically bind to numerous membrane targets through their 24 ankyrin repeats (ANK repeats), although the mechanism for the facile and independent evolution of these interactions has not been resolved. Here we report the structures of ANK repeats in complex with an inhibitory segment from the C-terminal regulatory domain and with a sodium channel Nav1.2 peptide, respectively, showing that the extended, extremely conserved inner groove spanning the entire ANK repeat solenoid contains multiple target binding sites capable of accommodating target proteins with very diverse sequences via combinatorial usage of these sites. These structures establish a framework for understanding the evolution of ankyrins' membrane targets, with implications for other proteins containing extended ANK repeat domains.
-The entry 4rly is ON HOLD  until Paper Publication
+Structural basis of diverse membrane target recognitions by ankyrins.,Wang C, Wei Z, Chen K, Ye F, Yu C, Bennett V, Zhang M Elife. 2014 Nov 10;3. doi: 10.7554/eLife.04353. PMID:25383926<ref>PMID:25383926</ref>
-Authors: Wei, Z., Wang, C., Zhang, M.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Crystal Structure of AnkB Ankyrin Repeats (R1-R9) in Complex with Nav1.2 Ankyrin Binding Domain
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Wang, C]]
+[[Category: Wei, Z]]
+[[Category: Zhang, M]]
+[[Category: Ank repeat]]
+[[Category: Protein-protein interaction]]
+[[Category: Structural protein]]