4kpe: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate==

~~The entry~~ 4kpe is ~~ON HOLD until Nov 26 2015~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4kpe]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPE OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KPE FirstGlance].

~~Authors~~: ~~Laponogov~~, I., ~~Pan, X~~.-S.~~, Vesekov, D~~.A., ~~Cirz, R~~.T., ~~Wagman, A~~.S., ~~Moser, H~~.E., Fisher, L.M., Sanderson, M.R.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=AF5:(7AR,8R)-8-AMINO-4-CYCLOPROPYL-12-FLUORO-1-OXO-4,7,7A,8,9,10-HEXAHYDRO-1H-PYRROLO[1,2 1,7]AZEPINO[2,3-H]QUINOLINE-2-CARBOXYLIC+ACID'>AF5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

~~Description~~: ~~Novel fluoroquinolones in complex with topoisomerase IV from~~ S~~. pneumoniae and E~~-~~site G~~-~~gate~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpe RCSB], [http://www.ebi.ac.uk/pdbsum/4kpe PDBsum]</td></tr>

</table>

__TOC__

</StructureSection>

[[Category: Cirz, R T]]

[[Category: Fisher, L M]]

[[Category: Laponogov, I]]

[[Category: Moser, H E]]

[[Category: Pan, X S]]

[[Category: Sanderson, M R]]

[[Category: Vesekov, D A]]

[[Category: Wagman, A S]]

[[Category: Achn-245]]

[[Category: Isomerase-dna-inhibitor complex]]

[[Category: Protein-dna cleavage complex]]

[[Category: Quinolone]]

[[Category: Topoisomerase iia]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate==
+<StructureSection load='4kpe' size='340' side='right' caption='[[4kpe]], [[Resolution|resolution]] 3.43&Aring;' scene=''>
-The entry 4kpe is ON HOLD  until Nov 26 2015
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4kpe]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KPE FirstGlance]. <br>
-Authors: Laponogov, I., Pan, X.-S., Vesekov, D.A., Cirz, R.T., Wagman, A.S., Moser, H.E., Fisher, L.M., Sanderson, M.R.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AF5:(7AR,8R)-8-AMINO-4-CYCLOPROPYL-12-FLUORO-1-OXO-4,7,7A,8,9,10-HEXAHYDRO-1H-PYRROLO[1,2 1,7]AZEPINO[2,3-H]QUINOLINE-2-CARBOXYLIC+ACID'>AF5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3foe|3foe]], [[3fof|3fof]], [[2nov|2nov]], [[3k9f|3k9f]], [[3ksa|3ksa]], [[3ksb|3ksb]], [[3ltn|3ltn]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[4koe|4koe]], [[4kpf|4kpf]]</td></tr>
-Description: Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpe RCSB], [http://www.ebi.ac.uk/pdbsum/4kpe PDBsum]</span></td></tr>
+</table>
+__TOC__
+</StructureSection>
+[[Category: Cirz, R T]]
+[[Category: Fisher, L M]]
+[[Category: Laponogov, I]]
+[[Category: Moser, H E]]
+[[Category: Pan, X S]]
+[[Category: Sanderson, M R]]
+[[Category: Vesekov, D A]]
+[[Category: Wagman, A S]]
+[[Category: Achn-245]]
+[[Category: Isomerase-dna-inhibitor complex]]
+[[Category: Protein-dna cleavage complex]]
+[[Category: Quinolone]]
+[[Category: Topoisomerase iia]]