4p5w: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structure of the N- and C-terminal domain fusion of the human mitochondrial aspartate/glutamate carrier Citrin in the calcium-bound state==

~~The entry~~ 4p5w is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4p5w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P5W FirstGlance]. <br>

~~Authors~~: ~~Thangaratnarajah~~, C., ~~Ruprecht~~, J.J.~~, Kunji, E~~.R.S.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p5w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p5w RCSB], [http://www.ebi.ac.uk/pdbsum/4p5w PDBsum]</span></td></tr>

~~Description~~: ~~Structure of~~ the ~~N-and C~~-~~terminal domain fusion~~ of the ~~human~~ mitochondrial ~~aspartate/glutamate carrier Citrin~~ in the ~~calcium-bound state~~

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/CMC2_HUMAN CMC2_HUMAN]] Citrullinemia type II;Neonatal intrahepatic cholestasis due to citrin deficiency. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/CMC2_HUMAN CMC2_HUMAN]] Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.<ref>PMID:11566871</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Kunji, E R.S]]

[[Category: Ruprecht, J J]]

[[Category: Thangaratnarajah, C]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structure of the N- and C-terminal domain fusion of the human mitochondrial aspartate/glutamate carrier Citrin in the calcium-bound state==
+<StructureSection load='4p5w' size='340' side='right' caption='[[4p5w]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-The entry 4p5w is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4p5w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P5W FirstGlance]. <br>
-Authors: Thangaratnarajah, C., Ruprecht, J.J., Kunji, E.R.S.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p5w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p5w RCSB], [http://www.ebi.ac.uk/pdbsum/4p5w PDBsum]</span></td></tr>
-Description: Structure of the N-and C-terminal domain fusion of the human mitochondrial aspartate/glutamate carrier Citrin in the calcium-bound state
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CMC2_HUMAN CMC2_HUMAN]] Citrullinemia type II;Neonatal intrahepatic cholestasis due to citrin deficiency. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/CMC2_HUMAN CMC2_HUMAN]] Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.<ref>PMID:11566871</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Kunji, E R.S]]
+[[Category: Ruprecht, J J]]
+[[Category: Thangaratnarajah, C]]
+[[Category: Transport protein]]