1m0g: Difference between revisions
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'''Solution structure of the alpha domain of mt_nc''' | {{Structure | ||
|PDB= 1m0g |SIZE=350|CAPTION= <scene name='initialview01'>1m0g</scene> | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CD:CADMIUM ION'>CD</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Solution structure of the alpha domain of mt_nc''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1M0G is a [ | 1M0G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Notothenia_coriiceps Notothenia coriiceps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M0G OCA]. | ||
==Reference== | ==Reference== | ||
Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps., Capasso C, Carginale V, Crescenzi O, Di Maro D, Parisi E, Spadaccini R, Temussi PA, Structure. 2003 Apr;11(4):435-43. PMID:[http:// | Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps., Capasso C, Carginale V, Crescenzi O, Di Maro D, Parisi E, Spadaccini R, Temussi PA, Structure. 2003 Apr;11(4):435-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12679021 12679021] | ||
[[Category: Notothenia coriiceps]] | [[Category: Notothenia coriiceps]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: cadmium-thiolate cluster]] | [[Category: cadmium-thiolate cluster]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:37:20 2008'' | ||
Revision as of 10:37, 20 March 2008
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| Ligands: | CD | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Solution structure of the alpha domain of mt_nc
Overview
The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish Notothenia coriiceps, the first three-dimensional structure of a fish metallothionein, was determined by homonuclear 1H NMR experiments and heteronuclear [1H, 113Cd]-correlation spectroscopy. MT_nc is composed of an N-terminal beta domain with 9 cysteines and 3 metal ions and a carboxy-terminal alpha-domain with 11 cysteines and 4 metal ions. The position of the ninth Cys of the alpha domain of MT_nc is different from the corresponding Cys of mammalian MTs. As a result, the last CXCC motif in the mammalian MT sequence becomes CXXXCC in the fish MT. This difference leads to a structural change of the alpha domain and, in turn, to a different charge distribution with respect to that observed in mammalian metallothioneins.
About this Structure
1M0G is a Single protein structure of sequence from Notothenia coriiceps. Full crystallographic information is available from OCA.
Reference
Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps., Capasso C, Carginale V, Crescenzi O, Di Maro D, Parisi E, Spadaccini R, Temussi PA, Structure. 2003 Apr;11(4):435-43. PMID:12679021
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