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[[Image:3ey2.png|left|200px]]
==A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution==
<StructureSection load='3ey2' size='340' side='right' caption='[[3ey2]], [[Resolution|resolution]] 1.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ey2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EY2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EY2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N3D:N-METHYLPROPANE-1,3-DIAMINE'>N3D</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=USM:2-S-METHYL-2-THIOURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>USM</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ey3|3ey3]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ey2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ey2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ey2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ey2 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Crystal structures of A-form and B-form DNA duplexes containing 2'-S-methyl-uridines reveal that the modified residues adopt a RNA-like C3'-endo pucker, illustrating that the replacement of electronegative oxygen at the 2'-carbon of RNA by sulfur does not appear to fundamentally alter the conformational preference of the sugar in the oligonucleotide context and sterics trump stereoelectronics.


{{STRUCTURE_3ey2|  PDB=3ey2  |  SCENE=  }}
A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.,Pallan PS, Prakash TP, Li F, Eoff RL, Manoharan M, Egli M Chem Commun (Camb). 2009 Apr 21;(15):2017-9. Epub 2009 Feb 26. PMID:19333476<ref>PMID:19333476</ref>


===A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_19333476}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3ey2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EY2 OCA].
</StructureSection>
 
[[Category: Egli, M]]
==Reference==
[[Category: Pallan, P S]]
<ref group="xtra">PMID:019333476</ref><references group="xtra"/>
[[Category: Egli, M.]]
[[Category: Pallan, P S.]]
[[Category: 2'-thiomethyl modified dna]]
[[Category: 2'-thiomethyl modified dna]]
[[Category: Dna]]
[[Category: Dna]]
[[Category: Modified sugar]]
[[Category: Modified sugar]]
[[Category: Nucleic acid structure.]]
[[Category: Nucleic acid structure]]
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