1m1j: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1m1j.gif|left|200px]] | [[Image:1m1j.gif|left|200px]] | ||
'''Crystal structure of native chicken fibrinogen with two different bound ligands''' | {{Structure | ||
|PDB= 1m1j |SIZE=350|CAPTION= <scene name='initialview01'>1m1j</scene>, resolution 2.70Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Crystal structure of native chicken fibrinogen with two different bound ligands''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
1M1J is a [ | 1M1J is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry 1JFE. The following page contains interesting information on the relation of 1M1J with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb83_1.html Fibrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1J OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of native chicken fibrinogen at 2.7 A resolution., Yang Z, Kollman JM, Pandi L, Doolittle RF, Biochemistry. 2001 Oct 23;40(42):12515-23. PMID:[http:// | Crystal structure of native chicken fibrinogen at 2.7 A resolution., Yang Z, Kollman JM, Pandi L, Doolittle RF, Biochemistry. 2001 Oct 23;40(42):12515-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11601975 11601975] | ||
[[Category: Fibrin]] | [[Category: Fibrin]] | ||
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
| Line 21: | Line 30: | ||
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: NDG]] | [[Category: NDG]] | ||
[[Category: coiled | [[Category: coiled coil]] | ||
[[Category: disulfide | [[Category: disulfide ring]] | ||
[[Category: fibrinogen]] | [[Category: fibrinogen]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:37:43 2008'' | ||
Revision as of 10:37, 20 March 2008
| |||||||||||||
| 1m1j, resolution 2.70Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | NDG, NAG and CA | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of native chicken fibrinogen with two different bound ligands
Overview
The crystal structure of native chicken fibrinogen (320 kDa) complexed with two synthetic peptides has been determined at a resolution of 2.7 A. The structure provides the first atomic-resolution view of the polypeptide chain arrangement in the central domain where the two halves of the molecule are joined, as well as of a putative thrombin-binding site. The amino-terminal segments of the alpha and beta chains, including fibrinopeptides A and B, are not visible in electron density maps, however, and must be highly disordered. The alphaC domain is also very disordered. A residue by residue analysis of the coiled coils with regard to temperature factor shows a strong correlation between mobility and plasmin attack sites. It is concluded that structural flexibility is an inherent feature of fibrinogen that plays a key role in both its conversion to fibrin and its subsequent destruction by plasmin.
About this Structure
1M1J is a Protein complex structure of sequences from Gallus gallus. This structure supersedes the now removed PDB entry 1JFE. The following page contains interesting information on the relation of 1M1J with [Fibrin]. Full crystallographic information is available from OCA.
Reference
Crystal structure of native chicken fibrinogen at 2.7 A resolution., Yang Z, Kollman JM, Pandi L, Doolittle RF, Biochemistry. 2001 Oct 23;40(42):12515-23. PMID:11601975
Page seeded by OCA on Thu Mar 20 12:37:43 2008
