3fbl: Difference between revisions
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[[ | ==Crystal structure of ORF132 of the archaeal virus Acidianus Filamentous Virus 1 (AFV1)== | ||
<StructureSection load='3fbl' size='340' side='right' caption='[[3fbl]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3fbl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acidianus_filamentous_virus_1 Acidianus filamentous virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FBL FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AFV1_ORF132 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235266 Acidianus filamentous virus 1])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fbl RCSB], [http://www.ebi.ac.uk/pdbsum/3fbl PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Acidianus filamentous virus 1 (AFV1), a member of the Lipothrixviridae family, infects the hyperthermophilic, acidophilic crenarchaeaon Acidianus hospitalis. The virion, covered with a lipidic outer shell, is 9,100-A long and contains a 20.8-kb linear dsDNA genome. We have identified the two major coat proteins of the virion (MCPs; 132 and 140 amino acids). They bind DNA and form filaments when incubated with linear dsDNA. A C-terminal domain is identified in their crystal structure with a four-helix-bundle fold. In the topological model of the virion filament core, the genomic dsDNA superhelix wraps around the AFV1-132 basic protein, and the AFV1-140 basic N terminus binds genomic DNA, while its lipophilic C-terminal domain is imbedded in the lipidic outer shell. The four-helix bundle fold of the MCPs from AFV1 is identical to that of the coat protein (CP) of Sulfolobus islandicus rod-shaped virus (SIRV), a member of the Rudiviridae family. Despite low sequence identity between these proteins, their high degree of structural similarity suggests that they could have derived from a common ancestor and could thus define an yet undescribed viral lineage. | |||
Acidianus filamentous virus 1 coat proteins display a helical fold spanning the filamentous archaeal viruses lineage.,Goulet A, Blangy S, Redder P, Prangishvili D, Felisberto-Rodrigues C, Forterre P, Campanacci V, Cambillau C Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21155-60. Epub 2009 Nov 23. PMID:19934032<ref>PMID:19934032</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Acidianus filamentous virus 1]] | [[Category: Acidianus filamentous virus 1]] | ||
[[Category: Cambillau, C | [[Category: Cambillau, C]] | ||
[[Category: Campanacci, V | [[Category: Campanacci, V]] | ||
[[Category: Goulet, A | [[Category: Goulet, A]] | ||
[[Category: Leulliot, N | [[Category: Leulliot, N]] | ||
[[Category: Prangishvili, D | [[Category: Prangishvili, D]] | ||
[[Category: Tilbeurgh, H van | [[Category: Tilbeurgh, H van]] | ||
[[Category: Afv1]] | [[Category: Afv1]] | ||
[[Category: Archaeal virus]] | [[Category: Archaeal virus]] | ||
Revision as of 08:49, 26 November 2014
Crystal structure of ORF132 of the archaeal virus Acidianus Filamentous Virus 1 (AFV1)
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