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[[Image:3epv.png|left|200px]]
==X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms==
<StructureSection load='3epv' size='340' side='right' caption='[[3epv]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3epv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupriavidus_metallidurans Cupriavidus metallidurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EPV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cnrR, cnrX, RMe0087, Rmet_6206 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119219 Cupriavidus metallidurans])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3epv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3epv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3epv RCSB], [http://www.ebi.ac.uk/pdbsum/3epv PDBsum]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ep/3epv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Both the X-ray structures of the apo- and the copper-bound forms of the metal-sensor domain (residues 31-148) of CnrX from Cupriavidus metallidurans CH34 were obtained at 1.74A resolution from a selenomethionine derivative. This four-helix hooked-hairpin is the first structure of a metal-sensor in an ECF-type signaling pathway. The copper ion is bound in a type 2-like center with a 3N1O coordination in the equatorial plane and shows an unprecedented remote fifth axial ligand with Met93 contributing a weak S-Cu bond. The signal onset cannot be explained by conformational changes associated with CnrX metallation.


{{STRUCTURE_3epv|  PDB=3epv  |  SCENE=  }}
X-ray structure of the metal-sensor CnrX in both the apo- and copper-bound forms.,Pompidor G, Maillard AP, Girard E, Gambarelli S, Kahn R, Coves J FEBS Lett. 2008 Nov 26;582(28):3954-8. Epub 2008 Nov 4. PMID:18992246<ref>PMID:18992246</ref>


===X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_18992246}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3epv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cupriavidus_metallidurans Cupriavidus metallidurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EPV OCA].
</StructureSection>
 
==Reference==
<ref group="xtra">PMID:018992246</ref><references group="xtra"/>
[[Category: Cupriavidus metallidurans]]
[[Category: Cupriavidus metallidurans]]
[[Category: Coves, J.]]
[[Category: Coves, J]]
[[Category: Gambarelli, S.]]
[[Category: Gambarelli, S]]
[[Category: Girard, E.]]
[[Category: Girard, E]]
[[Category: Kahn, R.]]
[[Category: Kahn, R]]
[[Category: Maillard, A P.]]
[[Category: Maillard, A P]]
[[Category: Pompidor, G.]]
[[Category: Pompidor, G]]
[[Category: All alpha helix]]
[[Category: All alpha helix]]
[[Category: Cobalt]]
[[Category: Cobalt]]
[[Category: Metal binding protein]]
[[Category: Metal binding protein]]
[[Category: Nickel]]
[[Category: Nickel]]
Retrieved from "https://proteopedia.org/3epv"