3f2n: Difference between revisions

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[[Image:3f2n.png|left|200px]]
==Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand==
<StructureSection load='3f2n' size='340' side='right' caption='[[3f2n]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3f2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3F2N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IZZ:(2S)-2-{[3-(3-AMINOPHENYL)IMIDAZO[1,2-B]PYRIDAZIN-6-YL]AMINO}-3-METHYLBUTAN-1-OL'>IZZ</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HASPIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f2n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f2n RCSB], [http://www.ebi.ac.uk/pdbsum/3f2n PDBsum]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/3f2n_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>


{{STRUCTURE_3f2n|  PDB=3f2n  |  SCENE=  }}
==See Also==
 
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
===Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand===
__TOC__
 
</StructureSection>
 
==About this Structure==
[[3f2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F2N OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C.]]
[[Category: Bountra, C]]
[[Category: Burgess-Brown, N.]]
[[Category: Burgess-Brown, N]]
[[Category: Delft, F Von.]]
[[Category: Delft, F Von]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: Eswaran, J.]]
[[Category: Eswaran, J]]
[[Category: Fedorov, O.]]
[[Category: Fedorov, O]]
[[Category: Filippakopoulos, P.]]
[[Category: Filippakopoulos, P]]
[[Category: Keates, T.]]
[[Category: Keates, T]]
[[Category: Knapp, S.]]
[[Category: Knapp, S]]
[[Category: Murray, J W.]]
[[Category: Murray, J W]]
[[Category: Pike, A C.W.]]
[[Category: Pike, A C.W]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Yue, W W.]]
[[Category: Yue, W W]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 08:56, 26 November 2014

Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand

3f2n, resolution 1.80Å

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