2mb2: Difference between revisions
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''' | ==parallel-stranded G-quadruplex in DNA poly-G stretches== | ||
<StructureSection load='2mb2' size='340' side='right' caption='[[2mb2]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mb2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MB2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MB2 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mb2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mb2 RCSB], [http://www.ebi.ac.uk/pdbsum/2mb2 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Poly-G sequences are found in different genomes including human and have the potential to form higher-order structures with various applications. Previously, long poly-G sequences were thought to lead to multiple possible ways of G-quadruplex folding, rendering their structural characterization challenging. Here we investigate the structure of G-quadruplexes formed by poly-G sequences d(TTGnT), where n = 12 to 19. Our data show the presence of multiple and/or higher-order G-quadruplex structures in most sequences. Strikingly, NMR spectra of the TTG15T sequence containing a stretch of 15 continuous guanines are exceptionally well-resolved and indicate the formation of a well-defined G-quadruplex structure. The NMR solution structure of this sequence revealed a propeller-type parallel-stranded G-quadruplex containing three G-tetrad layers and three single-guanine propeller loops. The same structure can potentially form anywhere along a long Gn stretch, making it unique for molecular recognition by other cellular molecules. | |||
Formation of G-Quadruplexes in Poly-G Sequences: Structure of a Propeller-Type Parallel-Stranded G-Quadruplex Formed by a G Stretch.,Sengar A, Heddi B, Phan AT Biochemistry. 2014 Dec 1. PMID:25375976<ref>PMID:25375976</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Heddi, B]] | |||
[[Category: Phan, A T]] | |||
[[Category: Sengar, A]] | |||
[[Category: Dna]] | |||
[[Category: G-quadruplex]] | |||
[[Category: G-tract]] | |||
[[Category: Poly-g stretch]] | |||
[[Category: Propeller structure]] | |||
Revision as of 09:29, 3 December 2014
parallel-stranded G-quadruplex in DNA poly-G stretches
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