2y1o: Difference between revisions
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[[ | ==Dual-target Inhibitor of MurD and MurE Ligases: Design, Synthesis and Binding Mode Studies== | ||
<StructureSection load='2y1o' size='340' side='right' caption='[[2y1o]], [[Resolution|resolution]] 1.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2y1o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_dh5[alpha] Escherichia coli dh5[alpha]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y1O FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T26:(2R)-2-[[3-[[4-[(Z)-(4-OXO-2-SULFANYLIDENE-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]PHENYL]METHYLAMINO]PHENYL]CARBONYLAMINO]PENTANEDIOIC+ACID'>T26</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wjp|2wjp]], [[2vtd|2vtd]], [[2uuo|2uuo]], [[2jfg|2jfg]], [[1uag|1uag]], [[4uag|4uag]], [[2uag|2uag]], [[2jfh|2jfh]], [[3uag|3uag]], [[2uup|2uup]], [[1e0d|1e0d]], [[2vte|2vte]], [[2jff|2jff]], [[2x5o|2x5o]], [[1eeh|1eeh]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanine--D-glutamate_ligase UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.9 6.3.2.9] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y1o RCSB], [http://www.ebi.ac.uk/pdbsum/2y1o PDBsum]</span></td></tr> | |||
</table> | |||
==See Also== | |||
*[[MurD ligase|MurD ligase]] | |||
== | __TOC__ | ||
</StructureSection> | |||
[[ | |||
[[Category: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase]] | [[Category: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase]] | ||
[[Category: Blanot, D | [[Category: Blanot, D]] | ||
[[Category: Contreras-Martel, C | [[Category: Contreras-Martel, C]] | ||
[[Category: Dessen, A | [[Category: Dessen, A]] | ||
[[Category: Gobec, S | [[Category: Gobec, S]] | ||
[[Category: Kikelj, D | [[Category: Kikelj, D]] | ||
[[Category: Kovac, A | [[Category: Kovac, A]] | ||
[[Category: Peterlin-Masic, L | [[Category: Peterlin-Masic, L]] | ||
[[Category: Sink, R | [[Category: Sink, R]] | ||
[[Category: Tomasic, T | [[Category: Tomasic, T]] | ||
[[Category: Turk, S | [[Category: Turk, S]] | ||
[[Category: Zega, A | [[Category: Zega, A]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Cell division]] | [[Category: Cell division]] | ||
