2l6i: Difference between revisions

Line 1:

[[~~Image~~:2l6i.~~png|left|200px~~]]

==Solution structure of coronaviral stem-loop 2 (SL2)==

== Structural highlights ==

<table><tr><td colspan='2'>[[2l6i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L6I FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l6i RCSB], [http://www.ebi.ac.uk/pdbsum/2l6i PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

The transcription and replication of the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is regulated by specific viral genome sequences within 5'- and 3'-untranslated regions (5'-UTR and 3'-UTR). Here we report the solution structure of 5'-UTR derived stem-loop 2 (SL2) of SARS-CoV determined by NMR spectroscopy. The highly conserved pentaloop of SL2 is stacked on 5-bp stem and adopts a canonical CUYG tetraloop fold with the 3' nucleotide (U51) flipped out of the stack. The significance of this structure in the context of a previous mutagenesis analysis of SL2 function in replication of the related group 2 coronavirus, mouse hepatitis virus, is discussed.

~~{{STRUCTURE_2l6i| PDB=2l6i | SCENE= }}~~

The solution structure of coronaviral stem-loop 2 (SL2) reveals a canonical CUYG tetraloop fold.,Lee CW, Li L, Giedroc DP FEBS Lett. 2011 Mar 4. PMID:21382373<ref>PMID:21382373</ref>

~~===Solution structure~~ of ~~coronaviral stem-loop 2 (SL2)===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_21382373}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[2l6i]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2L6I OCA].~~

</StructureSection>

[[Category: Giedroc, D P]]

==~~Reference~~==

[[Category: Lee, C]]

<~~ref group="xtra">PMID:021382373<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Li, L]]

[[Category: Giedroc, D P.]]

[[Category: Lee, C.]]

[[Category: Li, L.]]

[[Category: Coronavirus]]

[[Category: Mouse hepatitis virus]]

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@@ Line 1: / Line 1: @@
-[[Image:2l6i.png|left|200px]]
+==Solution structure of coronaviral stem-loop 2 (SL2)==
+<StructureSection load='2l6i' size='340' side='right' caption='[[2l6i]], [[NMR_Ensembles_of_Models | 27 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2l6i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L6I FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l6i RCSB], [http://www.ebi.ac.uk/pdbsum/2l6i PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The transcription and replication of the severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) is regulated by specific viral genome sequences within 5'- and 3'-untranslated regions (5'-UTR and 3'-UTR). Here we report the solution structure of 5'-UTR derived stem-loop 2 (SL2) of SARS-CoV determined by NMR spectroscopy. The highly conserved pentaloop of SL2 is stacked on 5-bp stem and adopts a canonical CUYG tetraloop fold with the 3' nucleotide (U51) flipped out of the stack. The significance of this structure in the context of a previous mutagenesis analysis of SL2 function in replication of the related group 2 coronavirus, mouse hepatitis virus, is discussed.
-{{STRUCTURE_2l6i|  PDB=2l6i  |  SCENE=  }}
+The solution structure of coronaviral stem-loop 2 (SL2) reveals a canonical CUYG tetraloop fold.,Lee CW, Li L, Giedroc DP FEBS Lett. 2011 Mar 4. PMID:21382373<ref>PMID:21382373</ref>
-===Solution structure of coronaviral stem-loop 2 (SL2)===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_21382373}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2l6i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6I OCA].
+</StructureSection>
+[[Category: Giedroc, D P]]
-==Reference==
+[[Category: Lee, C]]
-<ref group="xtra">PMID:021382373</ref><references group="xtra"/>
+[[Category: Li, L]]
-[[Category: Giedroc, D P.]]
-[[Category: Lee, C.]]
-[[Category: Li, L.]]
 [[Category: Coronavirus]]
 [[Category: Mouse hepatitis virus]]