Keithballard/sandbox: Difference between revisions
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===Function=== | ===Function=== | ||
sHSPs are believed to act as ATP independent molecular chaperones that are activated during proteotoxic stress by dissociating into an active form, presumably the sHSP dimer. This form has exposed hydrophobic regions which recognize and bind to hydrophobic patches on denaturing substrate protein. These interactions form a large, soluble, heterogeneous sHSP-substrate complex which can coordinate with ATP independent chaperones to refold substrate, or the degradation machinery for proteolysis. | sHSPs are believed to act as ATP independent molecular chaperones that are activated during proteotoxic stress by dissociating into an active form, presumably the sHSP dimer. This form has exposed hydrophobic regions which recognize and bind to hydrophobic patches on denaturing substrate protein. These interactions form a large, soluble, heterogeneous sHSP-substrate complex which can coordinate with ATP independent chaperones to refold substrate, or the degradation machinery for proteolysis. [http://www.ncbi.nlm.nih.gov/pubmed/22177323] | ||
===References=== | |||
