Reverse transcriptase: Difference between revisions

=== HIV-1 RT P66/P51===

[[3dlk]], [[1hmv]] - P66/P51<br />

[[1mu2]], [[1jle]], [[1hpz]], [[1hqu]], [[1qe1]], [[1dlo]], [[2wom]], [[2won]], [[3tam]], [[4dg1]] - P66/P51 (mutant)<br />

[[1har]] - P66 N-terminal<br />

[[3qip]] - P66/P51+NNRTI nevirapine + RNase H inhibitor<br />  

[[3lp0]], [[3lp1]], [[3lp2]], [[1vrt]], [[3hvt]] - P66/P51+NNRTI nevirapine<br />  

[[4i7f]] - P66/P51 + NNRTI nevirapine analog<br />

[[2hnd]], [[2hny]], [[1s1u]], [[1s1x]], [[1lw0]], [[1lwc]], [[1lwe]], [[1lwf]], [[1jlb]], [[1jlf]], [[1fkp]] - P66/P51 (mutant)+NNRTI nevirapine<br />

[[3m8p]], [[3mec]] - P66/P51+NNRTI etravirine<br />

[[3med]] - P66/P51 (mutant)+NNRTI etravirine<br />

[[3mee]], [[2zd1]], [[3qlh]] - P66/P51+NNRTI rilpivirine<br />

[[3meg]], [[2ze2]], [[3bgr]], [[4g1q]], [[4icl]], [[4id5]], [[4idk]], [[4ify]], [[4ig0]], [[4ig3]], [[4kfb]] - P66/P51 (mutant)+NNRTI rilpivirine<br />

[[1ikw]], [[1fk9]] - P66/P51 +NNRTI efavirenz<br />

[[1jkh]], [[1ikv]], [[1fko]] - P66/P51 (mutant)+NNRTI efavirenz<br />

[[3dya]], [[3e01]], [[3drp]] - P66/P51+NNRTI pyrazole<br />

[[3drr]], [[3drs]] - P66/P51 (mutant)+NNRTI pyrazole<br />

[[3irx]], [[3is9]], [[3lak]], [[3lal]], [[3lam]], [[3lan]], [[3ffi]], [[3di6]], [[3dle]], [[3dlg]], [[2rki]], [[3c6t]], [[3c6u]], [[2rf2]], [[2vg5]], [[2vg6]], [[2vg7]], [[2opp]], [[1jlq]], [[1ep4]], [[1c0t]], [[1c0u]], [[1dtt]], [[1dtq]], [[1bqm]], [[1rt1]], [[1rt2]], [[1rev]], [[1rtj]], [[1vru]], [[1hnv]], [[1hni]], [[3t19]] - P66/P51+NNRTI<br />

[[1s1t]], [[1s1v]], [[1s1w]], [[1s6p]], [[1s6q]], [[1s9e]], [[1s9g]], [[1suq]], [[1sv5]], [[3dm2]], [[3dmj]], [[3dok]], [[3dol]], [[2opq]], [[2opr]], [[2ops]], [[2ic3]], [[2hnz]], [[1jlg]], [[1bqn]], [[1uwb]], [[1tvr]], [[3qo9]], [[3t1a]]  - P66/P51 (mutant)+NNRTI<br />

[[3kk1]], [[1c1b]], [[1rti]], [[4kv8]] - P66/P51+ inhibitor<br />

[[2ynf]], [[2yng]], [[2ynf]], [[2yng]] - P66/P51 (mutant) + NNRTI <br />

[[1jla]] - P66/P51 (mutant)+ NRTI<br />

[[3ig1]] - P66/P51+ inhibitor beta-thujaplicinol<br />

[[3i0r]], [[3i0s]], [[3m8q]], [[3isn]], [[3ith]], [[1c1c]], [[3nbp]]  - P66/P51+ pyrimidine derivative<br />

[[1ikx]] - P66/P51 (mutant)+ pyrimidine derivative<br />

[[1tv6]] - P66/P51+ pyridine derivative<br />

[[1jlc]], [[1iky]], [[1eet]] - P66/P51(mutant)+ pyridine derivative<br />

[[2b5j]], [[2ban]], [[2be2]], [[1rth]], [[1hvt]] - P66/P51+ pyridone derivative<br />

[[1lw2]], [[1rt3]] - P66/P51 (mutant)+ NRTI<br />

[[1tkt]], [[1tkx]], [[1tkz]], [[1tl1]], [[1tl3]] - P66/P51+ quinoline derivative<br />

[[2b6a]] - P66/P51+ THR-50<br />  

[[2i5j]] - P66/P51 (mutant)+hydrazone derivative<br />

[[1rt4]], [[1rt5]], [[1rt6]], [[1rt7]] - P66/P51+ carboxanilide derivative<br />

[[1klm]] - P66/P51+piperazine derivative<br />

[[2jle]] – P66+NNRTI<br />

[[3kjv]], [[3kk3]], [[1r0a]], [[1n5y]], [[1n6q]], [[1hys]] - P66/P51+DNA<br />  

[[1j5o]], [[1rtd]], [[3klf]], [[3v4i]], [[3v6d]] - P66/P51 (mutant)+DNA<br />

[[3v81]] - P66/P51 (mutant)+DNA + NNRTI<br />

[[1hvu]] - P66/P51+RNA<br />  

[[4b3o]], [[4b3p]], [[4b3q]] - P66/P51 + RNA + DNA<br />

[[1t03]], [[1t05]] - P66/P51+DNA+Fab+NRTI<br />

[[3jsm]] - P66/P51 (mutant)+DNA+NRTI<br />

[[2hmi]] - P66/P51 (mutant)+DNA+Fab<br />

[[2iaj]] - P66/P51 (mutant)+NRTI<br />

[[3kk2]] - P66/P51+DNA+NRTI<br />

[[3jyt]] - P66/P51 (mutant)+DNA+NRTI<br />

===HIV-1 AZT-resistant RT P66/P51===

[[3kli]] - P66/P51 (mutant)<br />

[[3kle]], [[3klg]], [[3klh]] – P66/P51 (mutant) + DNA

===HIV-1 RT P66===

[[2jle]] – P66+NNRTI<br />

[[1har]] - P66 N-terminal

===HIV-1 RT P15===

[[1rdh]], [[1hrh]] – P15<br />

[[3lp3]] – P15+inhibitor MK3<br />

[[3k2p]] – P15+inhibitor beta-thujaplicinol<br />

[[3hyf]] – P15+pyrimidine derivative<br />

[[1o1w]] – P15+Mg - NMR<br />

===HIV-2 RT===

[[1mu2]] - RT (mutant)

=== Leukemia virus RT ===

[[2hb5]], [[1mml]] - catalytic fragment<br />

[[2r2r]], [[2r2t]], [[2fjv]], [[2fjw]], [[2fjx]], [[1ztw]], [[2fvs]], [[2fvr]], [[2fvq]], [[2fvp]], [[1n4l]] – catalytic fragment+DNA<br />

[[2r2s]], [[2r2u]] - catalytic fragment+DNA+Co Bleomycin<br />

[[1ztt]] - catalytic fragment+DNA+netropsin<br />

[[1rw3]], [[1nnd]] – fragment (mutant)<br />

[[1i6j]], [[1d0e]], [[1d1u]], [[1qaj]], [[1qai]] – N-terminal+DNA<br />

[[3fsi]] - catalytic fragment+DNA+trypanocidal

===XMRV RT===

[[3v1o]], [[3v1q]] – RNAse H domain<br />

[[3v1r]] – RNAse H domain + inhibitor<br />

[[4hkq]] – RT residues 658-1328 (mutant) + DNA + RNA<br />

[[2lsn]] – RT – Simian foamy virus - NMR

===RT from telomerase===

[[2b2a]] - RT telomerase catalytic subunit (mutant) - ''Tetrahymena thermophila''<br />

[[2r4g]] - RT telomerase RNA-binding domain<br />

[[3du6]], [[3du5]] - TcRT telomerase catalytic subunit - ''Tribolium castaneum''<br />

[[3kyl]] - TcRT telomerase catalytic subunit + DNA