1mlw: Difference between revisions

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[[Image:1mlw.gif|left|200px]]<br /><applet load="1mlw" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1mlw.gif|left|200px]]
caption="1mlw, resolution 1.71&Aring;" />
 
'''Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III)'''<br />
{{Structure
|PDB= 1mlw |SIZE=350|CAPTION= <scene name='initialview01'>1mlw</scene>, resolution 1.71&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> and <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Tryptophan_5-monooxygenase Tryptophan 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.4 1.14.16.4]
|GENE= TPH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1MLW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FE:'>FE</scene> and <scene name='pdbligand=HBI:'>HBI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1MLW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Active as [http://en.wikipedia.org/wiki/Tryptophan_5-monooxygenase Tryptophan 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.4 1.14.16.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MLW OCA].  
1MLW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1MLW with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MLW OCA].  


==Reference==
==Reference==
Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin., Wang L, Erlandsen H, Haavik J, Knappskog PM, Stevens RC, Biochemistry. 2002 Oct 22;41(42):12569-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12379098 12379098]
Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin., Wang L, Erlandsen H, Haavik J, Knappskog PM, Stevens RC, Biochemistry. 2002 Oct 22;41(42):12569-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12379098 12379098]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phenylalanine Hydroxylase]]
[[Category: Phenylalanine Hydroxylase]]
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[[Category: aromatic amino acid hydroxylase catalytic domain fold]]
[[Category: aromatic amino acid hydroxylase catalytic domain fold]]


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