3jrv: Difference between revisions

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[[Image:3jrv.png|left|200px]]
==Structure of poxvirus K7 protein in complex with RNA helicase DDX3==
<StructureSection load='3jrv' size='340' side='right' caption='[[3jrv]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3jrv]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus_wr Vaccinia virus wr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JRV FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jrv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jrv RCSB], [http://www.ebi.ac.uk/pdbsum/3jrv PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Poxviruses are DNA viruses that express numerous proteins to subvert the host immune response. Vaccinia virus protein K7 adopts a Bcl-2 fold and displays structural and functional similarities to Toll-like receptor antagonist A52. Both proteins interact with IRAK2 and TRAF6 and suppress TLR-dependent NF-kappaB activation. However, unlike A52, K7 also forms a complex with RNA helicase DDX3 and antagonizes interferon-beta promoter induction. We have narrowed the K7 binding site to an N-terminal peptide motif of DDX3 ahead of its core RNA-helicase domains. The crystal structure of full-length K7 in complex with the DDX3 peptide reveals a thumblike projection of tandem phenalyalanine residues of DDX3 into a deep hydrophobic cleft. Mutagenesis of these phenylalanines abolishes the effects of DDX3 on interferon-beta promoter induction. The structure of K7-DDX3 reveals a novel binding mode by a viral Bcl-2 protein that antagonizes a key pathway in innate immunity.


{{STRUCTURE_3jrv|  PDB=3jrv  |  SCENE=  }}
Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7.,Oda S, Schroder M, Khan AR Structure. 2009 Nov 11;17(11):1528-37. PMID:19913487<ref>PMID:19913487</ref>


===Structure of poxvirus K7 protein in complex with RNA helicase DDX3===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_19913487}}
 
==About this Structure==
[[3jrv]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus_wr Vaccinia virus wr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRV OCA].


==See Also==
==See Also==
*[[Helicase|Helicase]]
*[[Helicase|Helicase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019913487</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Vaccinia virus wr]]
[[Category: Vaccinia virus wr]]
[[Category: Khan, R A.]]
[[Category: Khan, R A]]
[[Category: Oda, S.]]
[[Category: Oda, S]]
[[Category: Dead-box rna helicase ddx3]]
[[Category: Dead-box rna helicase ddx3]]
[[Category: Innate immunity]]
[[Category: Innate immunity]]
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