3j2p: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:3j2p.png|left|200px]]
==CryoEM structure of Dengue virus capsid protein heterotetramer==
<StructureSection load='3j2p' size='340' side='right' caption='[[3j2p]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3j2p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J2P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3j27|3j27]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j2p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j2p RCSB], [http://www.ebi.ac.uk/pdbsum/3j2p PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Regulated by pH, membrane-anchored proteins E and M function during dengue virus maturation and membrane fusion. Our atomic model of the whole virion from cryo-electron microscopy at 3.5-A resolution reveals that in the mature virus at neutral extracellular pH, the N-terminal 20-amino-acid segment of M (involving three pH-sensing histidines) latches and thereby prevents spring-loaded E fusion protein from prematurely exposing its fusion peptide. This M latch is fastened at an earlier stage, during maturation at acidic pH in the trans-Golgi network. At a later stage, to initiate infection in response to acidic pH in the late endosome, M releases the latch and exposes the fusion peptide. Thus, M serves as a multistep chaperone of E to control the conformational changes accompanying maturation and infection. These pH-sensitive interactions could serve as targets for drug discovery.


{{STRUCTURE_3j2p|  PDB=3j2p  |  SCENE=  }}
Cryo-EM structure of the mature dengue virus at 3.5-A resolution.,Zhang X, Ge P, Yu X, Brannan JM, Bi G, Zhang Q, Schein S, Zhou ZH Nat Struct Mol Biol. 2012 Dec 16. doi: 10.1038/nsmb.2463. PMID:23241927<ref>PMID:23241927</ref>


===CryoEM structure of Dengue virus capsid protein heterotetramer===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_23241927}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3j2p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J2P OCA].
</StructureSection>
[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
[[Category: Bi, G.]]
[[Category: Bi, G]]
[[Category: Brannan, J M.]]
[[Category: Brannan, J M]]
[[Category: Ge, P.]]
[[Category: Ge, P]]
[[Category: Schein, S.]]
[[Category: Schein, S]]
[[Category: Yu, X.]]
[[Category: Yu, X]]
[[Category: Zhang, Q.]]
[[Category: Zhang, Q]]
[[Category: Zhang, X.]]
[[Category: Zhang, X]]
[[Category: Zhou, Z H.]]
[[Category: Zhou, Z H]]
[[Category: Flavivirus]]
[[Category: Flavivirus]]
[[Category: Fusion protein]]
[[Category: Fusion protein]]
Retrieved from "https://proteopedia.org/3j2p"