2l2f: Difference between revisions
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[[ | ==NMR Structure of GzCVNH (Gibberella zeae CVNH)== | ||
<StructureSection load='2l2f' size='340' side='right' caption='[[2l2f]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gibberella_zeae Gibberella zeae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L2F FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l2f RCSB], [http://www.ebi.ac.uk/pdbsum/2l2f PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Members of the cyanovirin-N homolog (CVNH) lectin family are found in bacteria, fungi and plants. As part of our ongoing work on CVNH structure-function studies, we determined the high-resolution NMR solution structure of the homolog from the wheat head blight disease causing ascomycetous fungus Gibberella zeae (or Fusarium graminearum), hereafter called GzCVNH. Like cyanovirin-N (CV-N), GzCVNH comprises two tandem sequence repeats and the protein sequence exhibits 30% identity with CV-N. The overall structure is similar to those of other members of the CVNH family, with the conserved pseudo-symmetric halves of the structure, domains A and B, closely resembling recently determined structures of Tuber borchii, Neurospora crassa, and Ceratopteris richardii CVNH proteins. Although GzCVNH exhibits a similar glycan recognition profile to CV-N and specifically binds to Manalpha(1-2)Manalpha, its weak carbohydrate binding affinity to only one binding site is insufficient for conferring anti-HIV activity. Proteins 2011; (c) 2011 Wiley-Liss, Inc. | |||
NMR solution structure of a cyanovirin homolog from wheat head blight fungus.,Matei E, Louis JM, Jee J, Gronenborn AM Proteins. 2011 Jan 18. doi: 10.1002/prot.22981. PMID:21365681<ref>PMID:21365681</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Gibberella zeae]] | [[Category: Gibberella zeae]] | ||
[[Category: Gronenborn, A M | [[Category: Gronenborn, A M]] | ||
[[Category: Jee, J G | [[Category: Jee, J G]] | ||
[[Category: Louis, J M | [[Category: Louis, J M]] | ||
[[Category: Matei, E | [[Category: Matei, E]] | ||
[[Category: Carbohydrate binding protein]] | [[Category: Carbohydrate binding protein]] | ||
[[Category: Cyanovirin-n homolog]] | [[Category: Cyanovirin-n homolog]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 09:13, 8 December 2014
NMR Structure of GzCVNH (Gibberella zeae CVNH)
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