1mrs: Difference between revisions

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[[Image:1mrs.gif|left|200px]]<br /><applet load="1mrs" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1mrs.gif|left|200px]]
caption="1mrs, resolution 2.00&Aring;" />
 
'''CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH 5-CH2OH DEOXYURIDINE MONOPHOSPHATE'''<br />
{{Structure
|PDB= 1mrs |SIZE=350|CAPTION= <scene name='initialview01'>1mrs</scene>, resolution 2.00&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=5HU:5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE'>5HU</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH 5-CH2OH DEOXYURIDINE MONOPHOSPHATE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1MRS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=5HU:'>5HU</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRS OCA].  
1MRS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MRS OCA].  


==Reference==
==Reference==
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism., Haouz A, Vanheusden V, Munier-Lehmann H, Froeyen M, Herdewijn P, Van Calenbergh S, Delarue M, J Biol Chem. 2003 Feb 14;278(7):4963-71. Epub 2002 Nov 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12454011 12454011]
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism., Haouz A, Vanheusden V, Munier-Lehmann H, Froeyen M, Herdewijn P, Van Calenbergh S, Delarue M, J Biol Chem. 2003 Feb 14;278(7):4963-71. Epub 2002 Nov 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12454011 12454011]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transferase (atp:tmp phosphotransferase)]]
[[Category: transferase (atp:tmp phosphotransferase)]]


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