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[[Image:3ajk.png|left|200px]]
==Crystal structure of d(CGCGGATf5UCGCG): 5-Formyluridine:Guanosine Base-pair in B-DNA with Hoechst33258==
<StructureSection load='3ajk' size='340' side='right' caption='[[3ajk]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ajk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AJK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HT:2-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5-BI-BENZIMIDAZOLE'>HT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UFR:2-DEOXY-5-FORMYLURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UFR</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ajj|3ajj]], [[3ajl|3ajl]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ajk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ajk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ajk RCSB], [http://www.ebi.ac.uk/pdbsum/3ajk PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. One of the major damaged thymine derivatives is 5-formyluracil (fU), which induces pyrimidine transition during replication. In order to establish the structural basis for such mutagenesis, the crystal structures of two kinds of DNA d(CGCGRATfUCGCG) with R = A/G have been determined by X-ray crystallography. The fU residues form a Watson-Crick-type pair with A and two types of pairs (wobble and reversed wobble) with G, the latter being a new type of base pair between ionized thymine base and guanine base. In silico structural modeling suggests that the DNA polymerase can accept the reversed wobble pair with G, as well as the Watson-Crick pair with A.


{{STRUCTURE_3ajk|  PDB=3ajk  |  SCENE=  }}
Insights into the structures of DNA damaged by hydroxyl radical: crystal structures of DNA duplexes containing 5-formyluracil.,Tsunoda M, Sakaue T, Naito S, Sunami T, Abe N, Ueno Y, Matsuda A, Takenaka A J Nucleic Acids. 2010 Oct 7;2010:107289. PMID:20976303<ref>PMID:20976303</ref>


===Crystal structure of d(CGCGGATf5UCGCG): 5-Formyluridine:Guanosine Base-pair in B-DNA with Hoechst33258===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_20976303}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[3ajk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AJK OCA].
</StructureSection>
 
[[Category: Matsuda, A]]
==Reference==
[[Category: Sakaue, T]]
<ref group="xtra">PMID:020976303</ref><references group="xtra"/>
[[Category: Takenaka, A]]
[[Category: Matsuda, A.]]
[[Category: Tsunoda, M]]
[[Category: Sakaue, T.]]
[[Category: Ueno, Y]]
[[Category: Takenaka, A.]]
[[Category: Tsunoda, M.]]
[[Category: Ueno, Y.]]
[[Category: Dna]]
[[Category: Dna]]
[[Category: Double helix]]
[[Category: Double helix]]
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