1ms6: Difference between revisions

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[[Image:1ms6.gif|left|200px]]<br /><applet load="1ms6" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ms6.gif|left|200px]]
caption="1ms6, resolution 1.90&Aring;" />
 
'''Dipeptide Nitrile Inhibitor Bound to Cathepsin S.'''<br />
{{Structure
|PDB= 1ms6 |SIZE=350|CAPTION= <scene name='initialview01'>1ms6</scene>, resolution 1.90&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=BLN:MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE'>BLN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27]
|GENE=
}}
 
'''Dipeptide Nitrile Inhibitor Bound to Cathepsin S.'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1MS6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BLN:'>BLN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA].  
1MS6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA].  


==Reference==
==Reference==
Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors., Ward YD, Thomson DS, Frye LL, Cywin CL, Morwick T, Emmanuel MJ, Zindell R, McNeil D, Bekkali Y, Girardot M, Hrapchak M, DeTuri M, Crane K, White D, Pav S, Wang Y, Hao MH, Grygon CA, Labadia ME, Freeman DM, Davidson W, Hopkins JL, Brown ML, Spero DM, J Med Chem. 2002 Dec 5;45(25):5471-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12459015 12459015]
Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors., Ward YD, Thomson DS, Frye LL, Cywin CL, Morwick T, Emmanuel MJ, Zindell R, McNeil D, Bekkali Y, Girardot M, Hrapchak M, DeTuri M, Crane K, White D, Pav S, Wang Y, Hao MH, Grygon CA, Labadia ME, Freeman DM, Davidson W, Hopkins JL, Brown ML, Spero DM, J Med Chem. 2002 Dec 5;45(25):5471-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12459015 12459015]
[[Category: Cathepsin S]]
[[Category: Cathepsin S]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: protease]]
[[Category: protease]]


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