2laq: Difference between revisions

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[[~~Image~~:2laq.~~png|left|200px~~]]

==Solution structure of the Sex Peptide from Drosophila melanogaster==

== Structural highlights ==

<table><tr><td colspan='2'>[[2laq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LAQ FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2laq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2laq RCSB], [http://www.ebi.ac.uk/pdbsum/2laq PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

The insect sex peptide (SP) elicits a variety of biological responses upon transfer to the mated female. SP contains 36 amino acids, including a tryptophan-rich N-terminal region, a central region containing five hydroxyproline (Hyp) residues, and a C-terminal region enclosed by a disulfide bridge. The solution structure of SP, studied here using NMR spectroscopy, includes a motif WPWN that adopts a type I beta-turn in the N-terminal Trp-rich region. This turn region is connected to the central Hyp-rich region, which adopts extended and/or PPII-like conformations. The C-terminal disulfide-bonded loop populates helical turns or nascent helical structure. Overall, the results reveal a rather flexible peptide that lacks a compact folded structure in solution.

~~{{STRUCTURE_2laq| PDB=2laq | SCENE= }}~~

NMR studies of the solution conformation of the sex peptide from Drosophila melanogaster.,Moehle K, Freund A, Kubli E, Robinson JA FEBS Lett. 2011 Apr 20;585(8):1197-202. Epub 2011 Mar 23. PMID:21439282<ref>PMID:21439282</ref>

~~===Solution structure~~ of the ~~Sex Peptide from Drosophila melanogaster===~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~{{ABSTRACT_PUBMED_21439282}}~~

== References ==

~~==About this Structure==~~

__TOC__

~~[[2laq]] is a 1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2LAQ OCA].~~

</StructureSection>

[[Category: Freund, A]]

==~~Reference~~==

[[Category: Moehle, K]]

<~~ref group="xtra">PMID:021439282<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Robinson, J A]]

[[Category: Freund, A.]]

[[Category: Moehle, K.]]

[[Category: Robinson, J A.]]

[[Category: Hydroxiproline rich]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-[[Image:2laq.png|left|200px]]
+==Solution structure of the Sex Peptide from Drosophila melanogaster==
+<StructureSection load='2laq' size='340' side='right' caption='[[2laq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2laq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LAQ FirstGlance]. <br>
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2laq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2laq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2laq RCSB], [http://www.ebi.ac.uk/pdbsum/2laq PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The insect sex peptide (SP) elicits a variety of biological responses upon transfer to the mated female. SP contains 36 amino acids, including a tryptophan-rich N-terminal region, a central region containing five hydroxyproline (Hyp) residues, and a C-terminal region enclosed by a disulfide bridge. The solution structure of SP, studied here using NMR spectroscopy, includes a motif WPWN that adopts a type I beta-turn in the N-terminal Trp-rich region. This turn region is connected to the central Hyp-rich region, which adopts extended and/or PPII-like conformations. The C-terminal disulfide-bonded loop populates helical turns or nascent helical structure. Overall, the results reveal a rather flexible peptide that lacks a compact folded structure in solution.
-{{STRUCTURE_2laq|  PDB=2laq  |  SCENE=  }}
+NMR studies of the solution conformation of the sex peptide from Drosophila melanogaster.,Moehle K, Freund A, Kubli E, Robinson JA FEBS Lett. 2011 Apr 20;585(8):1197-202. Epub 2011 Mar 23. PMID:21439282<ref>PMID:21439282</ref>
-===Solution structure of the Sex Peptide from Drosophila melanogaster===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_21439282}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2laq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAQ OCA].
+</StructureSection>
+[[Category: Freund, A]]
-==Reference==
+[[Category: Moehle, K]]
-<ref group="xtra">PMID:021439282</ref><references group="xtra"/>
+[[Category: Robinson, J A]]
-[[Category: Freund, A.]]
-[[Category: Moehle, K.]]
-[[Category: Robinson, J A.]]
 [[Category: Hydroxiproline rich]]
 [[Category: Signaling protein]]