3qt2: Difference between revisions

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[[Image:3qt2.png|left|200px]]
==Structure of a cytokine ligand-receptor complex==
<StructureSection load='3qt2' size='340' side='right' caption='[[3qt2]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3qt2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QT2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL5R, IL5RA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qt2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qt2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qt2 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Interleukin-5 (IL-5) is the key mediator for the function of eosinophil granulocytes, whose deregulation is characteristic of hypereosinophilic diseases and presumably contributes to allergic asthma. IL-5 signaling involves two transmembrane receptors, IL-5Ralpha and the common beta chain, which upon formation of the ternary complex activate the JAK/STAT signaling cascade. To investigate the mechanism underlying ligand-receptor recognition, we determined the structure of IL-5 bound to the extracellular domain of IL-5Ralpha. IL-5 makes contact with all three fibronectin III-like domains of IL-5Ralpha, with the receptor architecture resembling a wrench. Mutagenesis data provide evidence that this wrench-like architecture is likely preformed. The structure demonstrates that for steric reasons, homodimeric IL-5 can bind only one receptor molecule, even though two equivalent receptor-binding sites exist. In regard to strong efforts being made to develop IL-5 antagonists for treating asthma and hypereosinophilic diseases, the advances in molecular understanding provided by this structure are of greatest value.


{{STRUCTURE_3qt2|  PDB=3qt2  |  SCENE=  }}
Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha.,Patino E, Kotzsch A, Saremba S, Nickel J, Schmitz W, Sebald W, Mueller TD Structure. 2011 Dec 7;19(12):1864-75. PMID:22153509<ref>PMID:22153509</ref>


===Structure of a cytokine ligand-receptor complex===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_22153509}}
 
==About this Structure==
[[3qt2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QT2 OCA].


==See Also==
==See Also==
*[[Interleukin|Interleukin]]
*[[Interleukin receptor|Interleukin receptor]]
*[[Interleukin receptor|Interleukin receptor]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022153509</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kotzsch, A.]]
[[Category: Kotzsch, A]]
[[Category: Mueller, T D.]]
[[Category: Mueller, T D]]
[[Category: Nickel, J.]]
[[Category: Nickel, J]]
[[Category: Patino, E.]]
[[Category: Patino, E]]
[[Category: Saremba, S.]]
[[Category: Saremba, S]]
[[Category: Schmitz, W.]]
[[Category: Schmitz, W]]
[[Category: Sebald, W.]]
[[Category: Sebald, W]]
[[Category: Cytokine]]
[[Category: Cytokine]]
[[Category: Cytokine type i receptor fold]]
[[Category: Cytokine type i receptor fold]]
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