3p91: Difference between revisions
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[[ | ==Crystal structure of Proliferating Cellular Nuclear Antigen from Entamoeba histolytica== | ||
<StructureSection load='3p91' size='340' side='right' caption='[[3p91]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3p91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P91 FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EHI_128450 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5759 Entamoeba histolytica])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p91 RCSB], [http://www.ebi.ac.uk/pdbsum/3p91 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Proliferating cellular nuclear antigen (PCNA) is a toroidal-shaped protein that is involved in cell-cycle control, DNA replication and DNA repair. Parasitic protozoa are early-diverged eukaryotes that are responsible for neglected diseases. In this work, a PCNA from a parasitic protozoon was identified, cloned and biochemically characterized and its crystal structure was determined. Structural and biochemical studies demonstrate that PCNA from Entamoeba histolytica assembles as a homotrimer that is able to interact with and stimulate the activity of a PCNA-interacting peptide-motif protein from E. histolytica, EhDNAligI. The data indicate a conservation of the biochemical mechanisms of PCNA-mediated interactions between metazoa, yeast and parasitic protozoa. | |||
Structure and biochemical characterization of proliferating cellular nuclear antigen from a parasitic protozoon.,Cardona-Felix CS, Lara-Gonzalez S, Brieba LG Acta Crystallogr D Biol Crystallogr. 2011 Jun;67(Pt 6):497-505. Epub 2011 May 12. PMID:21636889<ref>PMID:21636889</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]] | *[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Entamoeba histolytica]] | [[Category: Entamoeba histolytica]] | ||
[[Category: Brieba, L G | [[Category: Brieba, L G]] | ||
[[Category: Cardona-Felix, C S | [[Category: Cardona-Felix, C S]] | ||
[[Category: Lara-Gonzalez, S | [[Category: Lara-Gonzalez, S]] | ||
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
[[Category: Dna replication]] | [[Category: Dna replication]] | ||
[[Category: Processivity]] | [[Category: Processivity]] | ||
[[Category: Sliding clamp]] | [[Category: Sliding clamp]] | ||
