3stk: Difference between revisions
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[[ | ==Crystal Structure of human LFABP complex with two molecules of palmitic acid (holo-LFABP)== | ||
<StructureSection load='3stk' size='340' side='right' caption='[[3stk]], [[Resolution|resolution]] 1.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3stk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3STK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3STK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3stm|3stm]], [[3stn|3stn]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3stk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3stk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3stk RCSB], [http://www.ebi.ac.uk/pdbsum/3stk PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We crystallized human liver fatty acid binding protein (LFABP) in apo, holo and intermediate states of palmitic acid engagement. Structural snapshots of fatty acid recognition, entry and docking within LFABP support a heads in mechanism for ligand entry. Apo-LFABP undergoes structural remodeling where first palmitate ingress creates atomic environment for placement of second palmitate. These new mechanistic insights will facilitate development of pharmacological agents against LFABP. | |||
Fatty acid induced remodeling within the Human liver fatty acid binding protein.,Sharma A, Sharma A J Biol Chem. 2011 Jul 8. PMID:21757748<ref>PMID:21757748</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Fatty acid-binding protein|Fatty acid-binding protein]] | *[[Fatty acid-binding protein|Fatty acid-binding protein]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Sharma, A | [[Category: Sharma, A]] | ||
[[Category: Fatty acid binding]] | [[Category: Fatty acid binding]] | ||
[[Category: Lfabp]] | [[Category: Lfabp]] | ||
[[Category: Lipid binding protein]] | [[Category: Lipid binding protein]] | ||
[[Category: Palmitic acid]] | [[Category: Palmitic acid]] | ||
Revision as of 11:30, 9 December 2014
Crystal Structure of human LFABP complex with two molecules of palmitic acid (holo-LFABP)
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