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[[Image:4a7a.png|left|200px]]
==Crystal structure of human monoamine oxidase B (MAO B) in complex with rosiglitazone==
<StructureSection load='4a7a' size='340' side='right' caption='[[4a7a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4a7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A7A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=RGZ:(R)-ROSIGLITAZONE'>RGZ</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c67|2c67]], [[3zyx|3zyx]], [[1s3e|1s3e]], [[2c73|2c73]], [[2v60|2v60]], [[1oj9|1oj9]], [[1ojd|1ojd]], [[2vz2|2vz2]], [[1s3b|1s3b]], [[2c66|2c66]], [[2xfo|2xfo]], [[2bk5|2bk5]], [[2c70|2c70]], [[1h8r|1h8r]], [[2xfn|2xfn]], [[2bk3|2bk3]], [[2c76|2c76]], [[2vrl|2vrl]], [[1oja|1oja]], [[2v5z|2v5z]], [[2xfu|2xfu]], [[2byb|2byb]], [[2vrm|2vrm]], [[2c65|2c65]], [[2xcg|2xcg]], [[2c64|2c64]], [[2xfp|2xfp]], [[2bk4|2bk4]], [[2c75|2c75]], [[2v61|2v61]], [[2c72|2c72]], [[1s2y|1s2y]], [[4a79|4a79]], [[1gos|1gos]], [[1s2q|1s2q]], [[2xfq|2xfq]], [[1ojc|1ojc]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Monoamine_oxidase Monoamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a7a RCSB], [http://www.ebi.ac.uk/pdbsum/4a7a PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The widely employed anti-diabetic drug pioglitazone (Actos) is shown to be a specific and reversible inhibitor of human monoamine oxidase B (MAO B). The crystal structure of the enzyme-inhibitor complex shows the R-enantiomer is bound with the thiazolidinedione ring near the flavin. The molecule occupies both substrate and entrance cavities of the active site establishing non-covalent interactions with the surrounding amino acids. These binding properties differentiate pioglitazone from the clinically used MAO inhibitors, which act through covalent inhibition mechanisms and do not exhibit a high degree of MAO A versus B selectivity. Rosiglitazone (Avandia) and troglitazone, other members of the glitazone class, are less selective in that they are weaker inhibitors of both MAO A and MAO B These results suggest that pioglitazone may have utility as a "re-purposed" neuro-protectant drug in retarding the progression of disease in Parkinson's patients. They also provide new insights for the development of reversible isoenzyme-specific MAO inhibitors.


{{STRUCTURE_4a7a|  PDB=4a7a  |  SCENE=  }}
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs.,Binda C, Aldeco M, Geldenhuys WJ, Tortorici M, Mattevi A, Edmondson DE ACS Med Chem Lett. 2011 Oct 15;3(1):39-42. PMID:22282722<ref>PMID:22282722</ref>


===Crystal structure of human monoamine oxidase B (MAO B) in complex with rosiglitazone===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_22282722}}
 
==About this Structure==
[[4a7a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A7A OCA].


==See Also==
==See Also==
*[[Monoamine oxidase|Monoamine oxidase]]
*[[Monoamine oxidase|Monoamine oxidase]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022282722</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Monoamine oxidase]]
[[Category: Monoamine oxidase]]
[[Category: Aldeco, M.]]
[[Category: Aldeco, M]]
[[Category: Binda, C.]]
[[Category: Binda, C]]
[[Category: Edmondson, D E.]]
[[Category: Edmondson, D E]]
[[Category: Geldenhuys, W J.]]
[[Category: Geldenhuys, W J]]
[[Category: Mattevi, A.]]
[[Category: Mattevi, A]]
[[Category: Tortorici, M.]]
[[Category: Tortorici, M]]
[[Category: Anti-diabetes drug]]
[[Category: Anti-diabetes drug]]
[[Category: Neurodegeneration]]
[[Category: Neurodegeneration]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Parkinson's disease]]
[[Category: Parkinson's disease]]
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