1npw: Difference between revisions

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[[Image:1npw.jpg|left|200px]]<br /><applet load="1npw" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1npw.jpg|left|200px]]
caption="1npw, resolution 2.&Aring;" />
 
'''Crystal structure of HIV protease complexed with LGZ479'''<br />
{{Structure
|PDB= 1npw |SIZE=350|CAPTION= <scene name='initialview01'>1npw</scene>, resolution 2.&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=LGZ:CARBAMIC ACID 1-{5-BENZYL-5-[2-HYDROXY-4-PHENYL-3-(TETRAHYDRO-FURAN- 3-YLOXYCARBONYLAMINO)-BUTYL]-4-OXO-4,5-DIHYDRO-1H-PYRROL-3-YL}- INDAN-2-YL ESTER'>LGZ</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Crystal structure of HIV protease complexed with LGZ479'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1NPW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=LGZ:'>LGZ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPW OCA].  
1NPW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPW OCA].  


==Reference==
==Reference==
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors., Smith AB 3rd, Cantin LD, Pasternak A, Guise-Zawacki L, Yao W, Charnley AK, Barbosa J, Sprengeler PA, Hirschmann R, Munshi S, Olsen DB, Schleif WA, Kuo LC, J Med Chem. 2003 May 8;46(10):1831-44. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12723947 12723947]
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors., Smith AB 3rd, Cantin LD, Pasternak A, Guise-Zawacki L, Yao W, Charnley AK, Barbosa J, Sprengeler PA, Hirschmann R, Munshi S, Olsen DB, Schleif WA, Kuo LC, J Med Chem. 2003 May 8;46(10):1831-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12723947 12723947]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: protease]]
[[Category: protease]]


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