3zp5: Difference between revisions

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~~[[Image:3zp5.jpg|left|200px]]~~

==Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA==

~~{{STRUCTURE_3zp5| PDB=3zp5 | SCENE= }}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3zp5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZP5 FirstGlance]. <br>

===Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA===

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zp5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp5 PDBsum]</span></td></tr>

</table>

== Disease ==

==~~About this Structure~~==

[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry. A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.

[[3zp5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP5 OCA].

== Function ==

[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Allerston, C K.]]

[[Category: Allerston, C K]]

[[Category: Arrowsmith, C H.]]

[[Category: Arrowsmith, C H]]

[[Category: Burgess-Brown, N.]]

[[Category: Burgess-Brown, N]]

[[Category: Cooper, C D.O.]]

[[Category: Cooper, C D.O]]

[[Category: Delft, F von.]]

[[Category: Delft, F von]]

[[Category: Edwards, A.]]

[[Category: Edwards, A]]

[[Category: Gileadi, O.]]

[[Category: Gileadi, O]]

[[Category: Krojer, T.]]

[[Category: Krojer, T]]

[[Category: Newman, J A.]]

[[Category: Newman, J A]]

[[Category: Shrestha, L.]]

[[Category: Shrestha, L]]

[[Category: Vollmar, M.]]

[[Category: Vollmar, M]]

[[Category: Transcription-dna complex]]

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@@ Line 1: / Line 1: @@
-[[Image:3zp5.jpg|left|200px]]
+==Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA==
+<StructureSection load='3zp5' size='340' side='right' caption='[[3zp5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-{{STRUCTURE_3zp5|  PDB=3zp5  |  SCENE=  }}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3zp5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZP5 FirstGlance]. <br>
-===Crystal structure of the DNA binding ETS domain of the human protein FEV in complex with DNA===
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zp5 RCSB], [http://www.ebi.ac.uk/pdbsum/3zp5 PDBsum]</span></td></tr>
+</table>
+== Disease ==
-==About this Structure==
+[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Disease susceptibility may be associated with variations affecting the gene represented in this entry.  A chromosomal aberration involving FEV is found in Ewing tumors. Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with a potential oncogenic activity.
-[[3zp5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZP5 OCA].
+== Function ==
+[[http://www.uniprot.org/uniprot/FEV_HUMAN FEV_HUMAN]] Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.<ref>PMID:12761502</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Allerston, C K.]]
+[[Category: Allerston, C K]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith, C H]]
-[[Category: Burgess-Brown, N.]]
+[[Category: Burgess-Brown, N]]
-[[Category: Cooper, C D.O.]]
+[[Category: Cooper, C D.O]]
-[[Category: Delft, F von.]]
+[[Category: Delft, F von]]
-[[Category: Edwards, A.]]
+[[Category: Edwards, A]]
-[[Category: Gileadi, O.]]
+[[Category: Gileadi, O]]
-[[Category: Krojer, T.]]
+[[Category: Krojer, T]]
-[[Category: Newman, J A.]]
+[[Category: Newman, J A]]
-[[Category: Shrestha, L.]]
+[[Category: Shrestha, L]]
-[[Category: Vollmar, M.]]
+[[Category: Vollmar, M]]
 [[Category: Transcription-dna complex]]