4aot: Difference between revisions
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[[ | ==Crystal Structure of Human Serine Threonine Kinase-10 (LOK) Bound to GW830263A== | ||
<StructureSection load='4aot' size='340' side='right' caption='[[4aot]], [[Resolution|resolution]] 2.33Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4aot]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AOT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GW8:1-(4-{METHYL[2-({4-[(METHYLSULFONYL)METHYL]PHENYL}AMINO)PYRIMIDIN-4-YL]AMINO}PHENYL)-3-{3-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]PHENYL}UREA'>GW8</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j7t|2j7t]], [[3zz2|3zz2]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aot RCSB], [http://www.ebi.ac.uk/pdbsum/4aot PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref> | |||
==See Also== | |||
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | |||
== | == References == | ||
<references/> | |||
__TOC__ | |||
== | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Arrowsmith, C | [[Category: Arrowsmith, C]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Canning, P | [[Category: Canning, P]] | ||
[[Category: Delft, F Von | [[Category: Delft, F Von]] | ||
[[Category: Edwards, A | [[Category: Edwards, A]] | ||
[[Category: Elkins, J M | [[Category: Elkins, J M]] | ||
[[Category: Knapp, S | [[Category: Knapp, S]] | ||
[[Category: Liu, Y | [[Category: Liu, Y]] | ||
[[Category: Salah, E | [[Category: Salah, E]] | ||
[[Category: Szklarz, M | [[Category: Szklarz, M]] | ||
[[Category: Yue, W | [[Category: Yue, W]] | ||
[[Category: Lok]] | [[Category: Lok]] | ||
[[Category: Stk10]] | [[Category: Stk10]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 16:24, 9 December 2014
Crystal Structure of Human Serine Threonine Kinase-10 (LOK) Bound to GW830263A
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