3uph: Difference between revisions
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[[ | ==Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors== | ||
<StructureSection load='3uph' size='340' side='right' caption='[[3uph]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3uph]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UPH FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0C1:6-(2,5-DIFLUOROBENZYL)-N-(METHYLSULFONYL)-8-(2-OXO-1,2-DIHYDROPYRIDIN-3-YL)-3,6-DIHYDRO-2H-FURO[2,3-E]INDOLE-7-CARBOXAMIDE'>0C1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3upi|3upi]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uph OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uph RCSB], [http://www.ebi.ac.uk/pdbsum/3uph PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The synthesis of substituted 3,4-dihydrofuranoindoles is reported. These new indole compounds were used to synthesize potent HCV NS5B inhibitors. The binding mode of the dihydrofuranoindole-derived inhibitors was established via X-ray crystallographic studies. | |||
Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors.,Velazquez F, Venkatraman S, Lesburg CA, Duca J, Rosenblum SB, Kozlowski JA, Njoroge FG Org Lett. 2012 Jan 20;14(2):556-9. Epub 2012 Jan 5. PMID:22220815<ref>PMID:22220815</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[RNA polymerase|RNA polymerase]] | *[[RNA polymerase|RNA polymerase]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
[[Category: Duca, J S | [[Category: Duca, J S]] | ||
[[Category: Kozlowski, J A | [[Category: Kozlowski, J A]] | ||
[[Category: Lesburg, C A | [[Category: Lesburg, C A]] | ||
[[Category: Njoroge, F G | [[Category: Njoroge, F G]] | ||
[[Category: Rosenblum, S B | [[Category: Rosenblum, S B]] | ||
[[Category: Velazquez, F | [[Category: Velazquez, F]] | ||
[[Category: Venkataraman, S | [[Category: Venkataraman, S]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 17:37, 9 December 2014
Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors
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