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==Crystallization and preliminary crystallographic analysis of human muscle phosphofructokinase, the main regulator of glycolysis==
==Crystal structure of human muscle phosphofructokinase (dissociated homodimer)==
<StructureSection load='4omt' size='340' side='right' caption='[[4omt]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
<StructureSection load='4omt' size='340' side='right' caption='[[4omt]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4omt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OMT FirstGlance]. <br>
<table><tr><td colspan='2'>[[4omt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OMT FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o8n|3o8n]], [[3opy|3opy]]</td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o8n|3o8n]], [[3opy|3opy]]</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4omt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4omt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4omt RCSB], [http://www.ebi.ac.uk/pdbsum/4omt PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4omt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4omt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4omt RCSB], [http://www.ebi.ac.uk/pdbsum/4omt PDBsum]</span></td></tr>
<table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/K6PF_HUMAN K6PF_HUMAN]] Glycogen storage disease due to muscle phosphofructokinase deficiency. The disease is caused by mutations affecting the gene represented in this entry.  
[[http://www.uniprot.org/uniprot/K6PF_HUMAN K6PF_HUMAN]] Glycogen storage disease due to muscle phosphofructokinase deficiency. The disease is caused by mutations affecting the gene represented in this entry.  
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</StructureSection>
</StructureSection>
[[Category: 6-phosphofructokinase]]
[[Category: 6-phosphofructokinase]]
[[Category: Kloos, M.]]
[[Category: Kloos, M]]
[[Category: Straeter, N.]]
[[Category: Straeter, N]]
[[Category: 6-phosphofructokinase activity]]
[[Category: 6-phosphofructokinase activity]]
[[Category: Fructose 6-phosphate]]
[[Category: Fructose 6-phosphate]]
[[Category: Human 6-phosphofructokinase]]
[[Category: Human 6-phosphofructokinase]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 11:27, 10 December 2014

Crystal structure of human muscle phosphofructokinase (dissociated homodimer)

4omt, resolution 6.00Å

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