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| ==Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements. This file, 1VSA, contains the 50S ribosome subunit. 30S ribosome subunit is in the file 2OW8==
| | #REDIRECT [[4v4i]] This PDB entry is obsolete and replaced by 4v4i |
| <StructureSection load='1vsa' size='340' side='right' caption='[[1vsa]], [[Resolution|resolution]] 3.71Å' scene=''>
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| == Structural highlights ==
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| <table><tr><td colspan='2'>[[1vsa]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1vs9 1vs9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VSA FirstGlance]. <br>
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| </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gix|1gix]], [[1giy|1giy]], [[2ow8|2ow8]]</td></tr>
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| <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vsa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vsa RCSB], [http://www.ebi.ac.uk/pdbsum/1vsa PDBsum]</span></td></tr>
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| <table>
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| == Evolutionary Conservation ==
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| [[Image:Consurf_key_small.gif|200px|right]]
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| Check<jmol>
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| <jmolCheckbox>
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| <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/1vsa_consurf.spt"</scriptWhenChecked>
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| <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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| <text>to colour the structure by Evolutionary Conservation</text>
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| </jmolCheckbox>
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| </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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| <div style="clear:both"></div>
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| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and high-resolution structures of ribosomal subunits and vacant ribosomes. Here, we present the crystal structure of the Thermus thermophilus 70S ribosome containing a model mRNA and two tRNAs at 3.7 A resolution. Many structural details of the interactions between the ribosome, tRNA, and mRNA in the P and E sites and the ways in which tRNA structure is distorted by its interactions with the ribosome are seen. Differences between the conformations of vacant and tRNA-bound 70S ribosomes suggest an induced fit of the ribosome structure in response to tRNA binding, including significant changes in the peptidyl-transferase catalytic site.
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| Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements.,Korostelev A, Trakhanov S, Laurberg M, Noller HF Cell. 2006 Sep 22;126(6):1065-77. Epub 2006 Sep 7. PMID:16962654<ref>PMID:16962654</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| ==See Also==
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| *[[Ribosome 3D structures|Ribosome 3D structures]]
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| == References ==
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| <references/>
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| __TOC__
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| </StructureSection>
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| [[Category: Thermus thermophilus]]
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| [[Category: Korostelev, A.]]
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| [[Category: Laurberg, M.]]
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| [[Category: Noller, H F.]]
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| [[Category: Trakhanov, S.]]
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| [[Category: E site]]
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| [[Category: Functional complex]]
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| [[Category: P site]]
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| [[Category: Peptidyl transferase center]]
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| [[Category: Ribosome]]
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| [[Category: Trna]]
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This PDB entry is obsolete and replaced by 4v4i
