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| ==STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME COMPLEXED WITH MRNA, TRNA AND PAROMOMYCIN (PART 2 OF 4). THIS FILE CONTAINS THE 50S SUBUNIT FROM MOLECULE I.==
| | #REDIRECT [[4v51]] This PDB entry is obsolete and replaced by 4v51 |
| <StructureSection load='2j01' size='340' side='right' caption='[[2j01]], [[Resolution|resolution]] 2.80Å' scene=''>
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| == Structural highlights ==
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| <table><tr><td colspan='2'>[[2j01]] is a 35 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J01 FirstGlance]. <br>
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| </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2j00|2j00]], [[2j02|2j02]], [[2j03|2j03]], [[1bxy|1bxy]], [[1twv|1twv]], [[2b66|2b66]], [[2b9n|2b9n]], [[2b9p|2b9p]]</td></tr>
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| <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j01 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j01 RCSB], [http://www.ebi.ac.uk/pdbsum/2j01 PDBsum]</span></td></tr>
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| <table>
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| == Evolutionary Conservation ==
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| [[Image:Consurf_key_small.gif|200px|right]]
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| Check<jmol>
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| <jmolCheckbox>
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| <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j0/2j01_consurf.spt"</scriptWhenChecked>
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| <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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| <text>to colour the structure by Evolutionary Conservation</text>
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| </jmolCheckbox>
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| </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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| <div style="clear:both"></div>
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| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and transfer RNA (tRNA). A metal ion stabilizes a kink in the mRNA that demarcates the boundary between A and P sites, which is potentially important to prevent slippage of mRNA. Metal ions also stabilize the intersubunit interface. The interactions of E-site tRNA with the 50S subunit have both similarities and differences compared to those in the archaeal ribosome. The structure also rationalizes much biochemical and genetic data on translation.
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| Structure of the 70S ribosome complexed with mRNA and tRNA.,Selmer M, Dunham CM, Murphy FV 4th, Weixlbaumer A, Petry S, Kelley AC, Weir JR, Ramakrishnan V Science. 2006 Sep 29;313(5795):1935-42. Epub 2006 Sep 7. PMID:16959973<ref>PMID:16959973</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| ==See Also==
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| *[[Large Ribosomal Subunit of Haloarcula|Large Ribosomal Subunit of Haloarcula]]
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| *[[Ribosome 3D structures|Ribosome 3D structures]]
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| *[[User:Wayne Decatur/Haloarcula Large Ribosomal Subunit|User:Wayne Decatur/Haloarcula Large Ribosomal Subunit]]
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| == References ==
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| <references/>
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| __TOC__
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| </StructureSection>
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| [[Category: Thermus thermophilus]]
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| [[Category: Dunham, C M.]]
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| [[Category: Kelley, A C.]]
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| [[Category: Murphy, F V.]]
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| [[Category: Petry, S.]]
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| [[Category: Ramakrishnan, V.]]
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| [[Category: Selmer, M.]]
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| [[Category: Weir, J R.]]
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| [[Category: Weixlbaumer, A.]]
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| [[Category: Mrna]]
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| [[Category: Paromomycin]]
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| [[Category: Ribosome]]
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| [[Category: Translation]]
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| [[Category: Trna]]
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This PDB entry is obsolete and replaced by 4v51
