4d1e: Difference between revisions
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''' | ==THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2== | ||
<StructureSection load='4d1e' size='340' side='right' caption='[[4d1e]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4d1e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D1E FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d1e RCSB], [http://www.ebi.ac.uk/pdbsum/4d1e PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[http://omim.org/entry/612158 612158]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Djinovic-Carugo, K]] | |||
[[Category: Gkougkoulia, E]] | |||
[[Category: Pinotsis, N]] | |||
[[Category: Salmazo, A]] | |||
[[Category: Sjoeblom, B]] | |||
[[Category: Abd]] | |||
[[Category: Actin binding domain]] | |||
[[Category: Calmodulin-like domain]] | |||
[[Category: Contractile protein]] | |||
[[Category: Spectrin domain]] | |||
[[Category: Z-disc]] | |||
Revision as of 16:19, 10 December 2014
THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2
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