1oon: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1oon.jpg|left|200px]]<br /><applet load="1oon" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1oon.jpg|left|200px]]
caption="1oon, resolution 2.49&Aring;" />
 
'''Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN27217'''<br />
{{Structure
|PDB= 1oon |SIZE=350|CAPTION= <scene name='initialview01'>1oon</scene>, resolution 2.49&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene> and <scene name='pdbligand=BEL:2,4-DINITRO,5-[BIS(2-BROMOETHYL)AMINO]-N-(2',3'-DIOXOPROPYL)BENZAMIDE'>BEL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34]
|GENE=
}}
 
'''Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN27217'''
 


==Overview==
==Overview==
Line 7: Line 16:


==About this Structure==
==About this Structure==
1OON is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=FMN:'>FMN</scene> and <scene name='pdbligand=BEL:'>BEL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OON OCA].  
1OON is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OON OCA].  


==Reference==
==Reference==
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form., Johansson E, Parkinson GN, Denny WA, Neidle S, J Med Chem. 2003 Sep 11;46(19):4009-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12954054 12954054]
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form., Johansson E, Parkinson GN, Denny WA, Neidle S, J Med Chem. 2003 Sep 11;46(19):4009-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12954054 12954054]
[[Category: 6,7-dihydropteridine reductase]]
[[Category: 6,7-dihydropteridine reductase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
Line 26: Line 35:
[[Category: sn27217]]
[[Category: sn27217]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:20:03 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:13:37 2008''
Retrieved from "https://proteopedia.org/1oon"