4i16: Difference between revisions

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[[Image:4i16.jpg|left|200px]]
==Crystal structure of CARMA1 CARD==
<StructureSection load='4i16' size='340' side='right' caption='[[4i16]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4i16]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I16 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I16 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Card11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i16 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4i16 RCSB], [http://www.ebi.ac.uk/pdbsum/4i16 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The CBM complex (CARMA1, BCL10 and MALT1) plays a crucial role in B and T lymphocyte activation. CARMA1 serves as a scaffold for BCL10, MALT1 and other effector proteins and regulates various signaling pathways related to the immune response. The assembly of CARMA1 and BCL10 is mediated through a CARD-CARD interaction. Here, we report the crystal structure of the CARD domain of CARMA1 at a resolution of 1.75 A. The structure consists of six helices, as previously determined for CARD domains. Structural and computational analysis identified the binding interface between CARMA1-CARD and BCL10-CARD, which consists of a basic patch in CARMA1 and an acidic patch in BCL10. Site-directed mutagenesis, co-immunoprecipitation and an NF-kappaB activation assay confirmed that the interface is necessary for association and downstream signaling. Our studies provide molecular insight into the assembly of CARMA1 and BCL10.


{{STRUCTURE_4i16|  PDB=4i16  |  SCENE=  }}
Structural insights into the assembly of CARMA1 and BCL10.,Li S, Yang X, Shao J, Shen Y PLoS One. 2012;7(8):e42775. doi: 10.1371/journal.pone.0042775. Epub 2012 Aug 3. PMID:22880103<ref>PMID:22880103</ref>


===Crystal structure of CARMA1 CARD===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
{{ABSTRACT_PUBMED_22880103}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[4i16]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I16 OCA].
</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Li, S.]]
[[Category: Li, S]]
[[Category: Shen, Y.]]
[[Category: Shen, Y]]
[[Category: Yang, X.]]
[[Category: Yang, X]]
[[Category: Bcl10 and malt1 binding]]
[[Category: Bcl10 and malt1 binding]]
[[Category: Cbm complex]]
[[Category: Cbm complex]]
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