4wyv

Crystal Structure of Human Translin in Open Conformation

spinqualitylabelsall models 4wyv, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4wyv is a 8 chain structure. This structure supersedes the now removed PDB entry 4jhf. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 4jhf Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The single-stranded DNA (ssDNA)/RNA binding protein translin was suggested to be involved in chromosomal translocations, telomere metabolism, and mRNA transport and translation. Oligonucleotide binding surfaces map within a closed cavity of translin octameric barrels, raising the question as to how DNA/RNA gain access to this inner cavity, particularly given that, to date, none of the barrel structures reported hint to an entryway. Here, we argue against a mechanism by which translin octamers may "dissociate and reassemble" upon RNA binding and report a novel "open"-barrel structure of human translin revealing a feasible DNA/RNA entryway into the cavity. Additionally, we report that translin not only is confined to binding of ssDNA oligonucleotides, or single-stranded extensions of double-stranded DNA (dsDNA), but also can bind single-stranded sequences internally embedded in dsDNA molecules. A Novel Open-Barrel Structure of Octameric Translin Reveals a Potential RNA Entryway.,Eliahoo E, Marx A, Manor H, Alian A J Mol Biol. 2014 Nov 26. pii: S0022-2836(14)00609-3. doi:, 10.1016/j.jmb.2014.11.013. PMID:25433126 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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