4qyk: Difference between revisions
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''' | ==Crystal structure of a canine parvivirus variant== | ||
<StructureSection load='4qyk' size='340' side='right' caption='[[4qyk]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4qyk]] is a 30 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QYK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qyk RCSB], [http://www.ebi.ac.uk/pdbsum/4qyk PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Canine parvovirus (CPV-2) emerged in 1978 and spread worldwide within two years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids. | |||
Global displacement of canine parvovirus by a host-adapted variant: A structural comparison between pandemic viruses with distinct host ranges.,Organtini LJ, Allison AB, Lukk T, Parrish CR, Hafenstein S J Virol. 2014 Nov 19. pii: JVI.02611-14. PMID:25410876<ref>PMID:25410876</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hafenstein, S U]] | |||
[[Category: Lukk, T]] | |||
[[Category: Organtini, L J]] | |||
[[Category: Capsid protein]] | |||
[[Category: Virus]] | |||
Revision as of 09:10, 17 December 2014
Crystal structure of a canine parvivirus variant
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