1ove: Difference between revisions

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[[Image:1ove.jpg|left|200px]]<br /><applet load="1ove" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1ove.jpg|left|200px]]
caption="1ove, resolution 2.1&Aring;" />
 
'''The structure of p38 alpha in complex with a dihydroquinolinone'''<br />
{{Structure
|PDB= 1ove |SIZE=350|CAPTION= <scene name='initialview01'>1ove</scene>, resolution 2.1&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=358:1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE'>358</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
|GENE= MAPK14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''The structure of p38 alpha in complex with a dihydroquinolinone'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1OVE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=358:'>358</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OVE OCA].  
1OVE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OVE OCA].  


==Reference==
==Reference==
Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity., Fitzgerald CE, Patel SB, Becker JW, Cameron PM, Zaller D, Pikounis VB, O'Keefe SJ, Scapin G, Nat Struct Biol. 2003 Sep;10(9):764-9. Epub 2003 Aug 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12897767 12897767]
Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity., Fitzgerald CE, Patel SB, Becker JW, Cameron PM, Zaller D, Pikounis VB, O'Keefe SJ, Scapin G, Nat Struct Biol. 2003 Sep;10(9):764-9. Epub 2003 Aug 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12897767 12897767]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: map kinase]]
[[Category: map kinase]]


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