|
|
| Line 1: |
Line 1: |
| ==Crystal structure of the Lactate Dehydrogenase from Cryptosporidium parvum complexed with substrate (Pyruvic acid) and cofactor (b-Nicotinamide adenine dinucleotide)==
| | #REDIRECT [[4nd4]] This PDB entry is obsolete and replaced by 4nd4 |
| <StructureSection load='2fm3' size='340' side='right' caption='[[2fm3]], [[Resolution|resolution]] 2.20Å' scene=''>
| |
| == Structural highlights ==
| |
| <table><tr><td colspan='2'>[[2fm3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FM3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FM3 FirstGlance]. <br>
| |
| </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene><br>
| |
| <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ewd|2ewd]]</td></tr>
| |
| <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
| |
| <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fm3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fm3 RCSB], [http://www.ebi.ac.uk/pdbsum/2fm3 PDBsum]</span></td></tr>
| |
| <table>
| |
| == Evolutionary Conservation ==
| |
| [[Image:Consurf_key_small.gif|200px|right]]
| |
| Check<jmol>
| |
| <jmolCheckbox>
| |
| <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/2fm3_consurf.spt"</scriptWhenChecked>
| |
| <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
| |
| <text>to colour the structure by Evolutionary Conservation</text>
| |
| </jmolCheckbox>
| |
| </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
| |
| <div style="clear:both"></div>
| |
| | |
| ==See Also==
| |
| *[[Lactate Dehydrogenase|Lactate Dehydrogenase]]
| |
| __TOC__
| |
| </StructureSection>
| |
| [[Category: Cryptosporidium parvum]]
| |
| [[Category: L-lactate dehydrogenase]]
| |
| [[Category: Chattopadhyay, D.]]
| |
| [[Category: Senkovich, O A.]]
| |
| [[Category: Oxidoreductase]]
| |
| [[Category: Protein-substrate-cofactor complex]]
| |
This PDB entry is obsolete and replaced by 4nd4
