2b9z: Difference between revisions
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==Solution structure of FHV B2, a viral suppressor of RNAi== | |||
=== | <StructureSection load='2b9z' size='340' side='right' caption='[[2b9z]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2b9z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B9Z FirstGlance]. <br> | |||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12287 Flock house virus])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b9z RCSB], [http://www.ebi.ac.uk/pdbsum/2b9z PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We report the structure of the flock house virus B2 protein, a potent suppressor of RNA interference (RNAi) in animals and plants. The B2 protein is a homodimer in solution and contains three alpha-helices per monomer. Chemical shift perturbation shows that an antiparallel arrangement of helices (alpha2/alpha2') forms an elongated binding interface with double-stranded RNA (dsRNA). This implies a novel mode of dsRNA recognition and provides insights into the mechanism of RNAi suppression by B2. | |||
The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition.,Lingel A, Simon B, Izaurralde E, Sattler M EMBO Rep. 2005 Dec;6(12):1149-55. PMID:16270100<ref>PMID:16270100</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
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*[[User:Wayne Decatur/Suppression of RNA Silencing by Viruses|User:Wayne Decatur/Suppression of RNA Silencing by Viruses]] | *[[User:Wayne Decatur/Suppression of RNA Silencing by Viruses|User:Wayne Decatur/Suppression of RNA Silencing by Viruses]] | ||
*[[User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing|User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing]] | *[[User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing|User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Flock house virus]] | [[Category: Flock house virus]] | ||
[[Category: Izaurralde, E | [[Category: Izaurralde, E]] | ||
[[Category: Lingel, A | [[Category: Lingel, A]] | ||
[[Category: Sattler, M | [[Category: Sattler, M]] | ||
[[Category: Simon, B | [[Category: Simon, B]] | ||
[[Category: All alpha-helical]] | [[Category: All alpha-helical]] | ||
[[Category: Symmetric antiparallel homodimer]] | [[Category: Symmetric antiparallel homodimer]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
