2fd4: Difference between revisions
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==Crystal Structure of AvrPtoB (436-553)== | |||
<StructureSection load='2fd4' size='340' side='right' caption='[[2fd4]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2fd4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FD4 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2fd4 RCSB], [http://www.ebi.ac.uk/pdbsum/2fd4 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The Pseudomonas syringae protein AvrPtoB is translocated into plant cells, where it inhibits immunity-associated programmed cell death (PCD). The structure of a C-terminal domain of AvrPtoB that is essential for anti-PCD activity reveals an unexpected homology to the U-box and RING-finger components of eukaryotic E3 ubiquitin ligases, and we show that AvrPtoB has ubiquitin ligase activity. Mutation of conserved residues involved in the binding of E2 ubiquitin-conjugating enzymes abolishes this activity in vitro, as well as anti-PCD activity in tomato leaves, which dramatically decreases virulence. These results show that Pseudomonas syringae uses a mimic of host E3 ubiquitin ligases to inactivate plant defenses. | |||
A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase.,Janjusevic R, Abramovitch RB, Martin GB, Stebbins CE Science. 2006 Jan 13;311(5758):222-6. Epub 2005 Dec 22. PMID:16373536<ref>PMID:16373536</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Avirulence protein|Avirulence protein]] | *[[Avirulence protein|Avirulence protein]] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Pseudomonas syringae]] | [[Category: Pseudomonas syringae]] | ||
[[Category: Janjusevic, R | [[Category: Janjusevic, R]] | ||
[[Category: Stebbins, C E | [[Category: Stebbins, C E]] | ||
[[Category: Avrptob]] | [[Category: Avrptob]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
