1p4r: Difference between revisions

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[[Image:1p4r.jpg|left|200px]]~~<br /><applet load~~="1p4r~~" size~~="350~~" color~~=~~"white" frame~~=~~"true" align="right" spinBox="true"~~

[[Image:1p4r.jpg|left|200px]]

~~caption="~~1p4r, resolution 2.55Å" />

'''Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD'''~~<br />~~

{{Structure

|PDB= 1p4r |SIZE=350|CAPTION= <scene name='initialview01'>1p4r</scene>, resolution 2.55Å

|SITE=

|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=354:N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC+ACID'>354</scene> and <scene name='pdbligand=XMP:XANTHOSINE-5'-MONOPHOSPHATE'>XMP</scene>

|ACTIVITY=

|GENE= ATIC cDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])

}}

'''Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD'''

==Overview==

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==About this Structure==

1P4R is a [~~http://en.wikipedia.org/wiki/Single_protein~~ Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=AMZ:'>AMZ</scene>, <scene name='pdbligand=354:'>354</scene> and <scene name='pdbligand=XMP:'>XMP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P4R OCA].

1P4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P4R OCA].

==Reference==

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates., Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA, J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:[http://~~ispc~~.~~weizmann~~.ac.~~il/~~/~~pmbin~~/~~getpm?pmid=~~14966129 14966129]

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates., Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA, J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14966129 14966129]

[[Category: Homo sapiens]]

[[Category: Single protein]]

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[[Category: purine biosynthesis]]

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@@ Line 1: / Line 1: @@
-[[Image:1p4r.jpg|left|200px]]<br /><applet load="1p4r" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1p4r.jpg|left|200px]]
-caption="1p4r, resolution 2.55&Aring;" />
-'''Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD'''<br />
+ {{Structure
+|PDB= 1p4r |SIZE=350|CAPTION= <scene name='initialview01'>1p4r</scene>, resolution 2.55&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=354:N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC+ACID'>354</scene> and <scene name='pdbligand=XMP:XANTHOSINE-5'-MONOPHOSPHATE'>XMP</scene>
+|ACTIVITY=
+|GENE= ATIC cDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD'''
 ==Overview==
@@ Line 10: / Line 19: @@
 ==About this Structure==
-P4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=AMZ:'>AMZ</scene>, <scene name='pdbligand=354:'>354</scene> and <scene name='pdbligand=XMP:'>XMP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P4R OCA].
+P4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P4R OCA].
 ==Reference==
-Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates., Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA, J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14966129 14966129]
+Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates., Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA, J Biol Chem. 2004 Apr 23;279(17):18034-45. Epub 2004 Feb 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14966129 14966129]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 30: / Line 39: @@
 [[Category: purine biosynthesis]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:25:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:19:49 2008''