1nj0: Difference between revisions
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==NMR structure of a V3 (MN isolate) peptide bound to 447-52D, a human HIV-1 neutralizing antibody== | |||
<StructureSection load='1nj0' size='340' side='right' caption='[[1nj0]], [[NMR_Ensembles_of_Models | 29 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1nj0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NJ0 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1niz|1niz]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ENV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nj0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nj0 RCSB], [http://www.ebi.ac.uk/pdbsum/1nj0 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The V3 loop of the HIV-1 envelope glycoprotein gp120 is involved in binding to the CCR5 and CXCR4 coreceptors. The structure of an HIV-1(MN) V3 peptide bound to the Fv of the broadly neutralizing human monoclonal antibody 447-52D was solved by NMR and found to be a beta hairpin. This structure of V3(MN) was found to have conformation and sequence similarities to beta hairpins in CD8 and CCR5 ligands MIP-1alpha, MIP-1beta, and RANTES and differed from the beta hairpin of a V3(IIIB) peptide bound to the strain-specific murine anti-gp120(IIIB) antibody 0.5beta. In contrast to the structure of the bound V3(MN) peptide, the V3(IIIB) peptide resembles a beta hairpin in SDF-1, a CXCR4 ligand. These data suggest that the 447-52D-bound V3(MN) and the 0.5beta-bound V3(IIIB) structures represent alternative V3 conformations responsible for selective interactions with CCR5 and CXCR4, respectively. | |||
Alternative conformations of HIV-1 V3 loops mimic beta hairpins in chemokines, suggesting a mechanism for coreceptor selectivity.,Sharon M, Kessler N, Levy R, Zolla-Pazner S, Gorlach M, Anglister J Structure. 2003 Feb;11(2):225-36. PMID:12575942<ref>PMID:12575942</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Gp120|Gp120]] | *[[Gp120|Gp120]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Anglister, J | [[Category: Anglister, J]] | ||
[[Category: Gorlach, M | [[Category: Gorlach, M]] | ||
[[Category: Kessler, N | [[Category: Kessler, N]] | ||
[[Category: Levy, R | [[Category: Levy, R]] | ||
[[Category: Sharon, M | [[Category: Sharon, M]] | ||
[[Category: Zolla-Pazner, S | [[Category: Zolla-Pazner, S]] | ||
[[Category: B-hairpin]] | [[Category: B-hairpin]] | ||
[[Category: Peptide-antibody complex]] | [[Category: Peptide-antibody complex]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
