1p9f: Difference between revisions
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'''NMR Structure of Neurokinin B from DYANA''' | {{Structure | ||
|PDB= 1p9f |SIZE=350|CAPTION= <scene name='initialview01'>1p9f</scene> | |||
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|LIGAND= | |||
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'''NMR Structure of Neurokinin B from DYANA''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1P9F is a [ | 1P9F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA]. | ||
==Reference== | ==Reference== | ||
Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles., Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM, J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:[http:// | Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles., Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM, J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15317475 15317475] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Baquer, N Z.]] | [[Category: Baquer, N Z.]] | ||
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[[Category: structures from dyana]] | [[Category: structures from dyana]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:21:39 2008'' | ||
Revision as of 11:21, 20 March 2008
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NMR Structure of Neurokinin B from DYANA
Overview
Neurokinin B (NKB), a decapeptide of mammalian origin exhibits a variety of biological activities such as regulatory functions in reproduction, pre-eclampsia and neuroprotection in Alzheimer's disease. In order to gain insight into structure-function relationship, three-dimensional structure of NKB has been investigated using CD spectropolarimetry and two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in aqueous and membrane mimetic solvents. Unambiguous NMR assignments of resonances have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and Nuclear Overhauser Effect Spectroscopy (NOESY) experiments. Distance constraints obtained from the NMR data have been used to generate a family of structures, which have been refined using restrained energy minimization and dynamics. Our data show that a helical structure is induced in NKB, in presence of perdeuterated dodecyl phosphocholine (DPC) micelles, a membrane model system. Further, the conformation adopted by NKB in presence of DPC micelles represents a structural motif typical of neurokinin-3 selective agonists.
About this Structure
1P9F is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles., Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM, J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:15317475
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