3ztn: Difference between revisions
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==STRUCTURE OF INFLUENZA A NEUTRALIZING ANTIBODY SELECTED FROM CULTURES OF SINGLE HUMAN PLASMA CELLS IN COMPLEX WITH HUMAN H1 INFLUENZA HAEMAGGLUTININ.== | |||
<StructureSection load='3ztn' size='340' side='right' caption='[[3ztn]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3ztn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZTN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ztn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ztn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ztn RCSB], [http://www.ebi.ac.uk/pdbsum/3ztn PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The isolation of broadly neutralizing antibodies against influenza A viruses has been a long-sought goal for therapeutic approaches and vaccine design. Using a single-cell culture method for screening large numbers of human plasma cells, we isolated a neutralizing monoclonal antibody that recognized the hemagglutinin (HA) glycoprotein of all 16 subtypes and neutralized both group 1 and group 2 influenza A viruses. Passive transfer of this antibody conferred protection to mice and ferrets. Complexes with HAs from the group 1 H1 and the group 2 H3 subtypes analyzed by x-ray crystallography showed that the antibody bound to a conserved epitope in the F subdomain. This antibody may be used for passive protection and to inform vaccine design because of its broad specificity and neutralization potency. | |||
A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins.,Corti D, Voss J, Gamblin SJ, Codoni G, Macagno A, Jarrossay D, Vachieri SG, Pinna D, Minola A, Vanzetta F, Silacci C, Fernandez-Rodriguez BM, Agatic G, Bianchi S, Giacchetto-Sasselli I, Calder L, Sallusto F, Collins P, Haire LF, Temperton N, Langedijk JP, Skehel JJ, Lanzavecchia A Science. 2011 Jul 28. PMID:21798894<ref>PMID:21798894</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Antibody|Antibody]] | *[[Antibody|Antibody]] | ||
*[[Hemagglutinin|Hemagglutinin]] | *[[Hemagglutinin|Hemagglutinin]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Influenza a virus]] | [[Category: Influenza a virus]] | ||
[[Category: Agatic, G | [[Category: Agatic, G]] | ||
[[Category: Codoni, G | [[Category: Codoni, G]] | ||
[[Category: Collins, P J | [[Category: Collins, P J]] | ||
[[Category: Corti, D | [[Category: Corti, D]] | ||
[[Category: Fernandez-Rodriguez, B M | [[Category: Fernandez-Rodriguez, B M]] | ||
[[Category: Gamblin, S J | [[Category: Gamblin, S J]] | ||
[[Category: Giacchetto-Sasselli, I | [[Category: Giacchetto-Sasselli, I]] | ||
[[Category: Haire, L F | [[Category: Haire, L F]] | ||
[[Category: Hubbard, P A | [[Category: Hubbard, P A]] | ||
[[Category: Jarrossay, D | [[Category: Jarrossay, D]] | ||
[[Category: Langedijk, J P.M | [[Category: Langedijk, J P.M]] | ||
[[Category: Lanzavecchia, A | [[Category: Lanzavecchia, A]] | ||
[[Category: Macagno, A | [[Category: Macagno, A]] | ||
[[Category: Minola, A | [[Category: Minola, A]] | ||
[[Category: Pinna, D | [[Category: Pinna, D]] | ||
[[Category: Ritchie, A J | [[Category: Ritchie, A J]] | ||
[[Category: Sallusto, F | [[Category: Sallusto, F]] | ||
[[Category: Silacci, C | [[Category: Silacci, C]] | ||
[[Category: Skehel, J J | [[Category: Skehel, J J]] | ||
[[Category: Temperton, N | [[Category: Temperton, N]] | ||
[[Category: Vachieri, S G | [[Category: Vachieri, S G]] | ||
[[Category: Vanzetta, F | [[Category: Vanzetta, F]] | ||
[[Category: Voss, J E | [[Category: Voss, J E]] | ||
[[Category: Monoclonal antibody | [[Category: Monoclonal antibody]] | ||
[[Category: Viral protein-immune system complex]] | [[Category: Viral protein-immune system complex]] | ||
