3odv: Difference between revisions
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==X-ray structure of kaliotoxin by racemic protein crystallography== | |||
===X-ray structure of kaliotoxin by | <StructureSection load='3odv' size='340' side='right' caption='[[3odv]], [[Resolution|resolution]] 0.95Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3odv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ODV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3odv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3odv RCSB], [http://www.ebi.ac.uk/pdbsum/3odv PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Here we report the total synthesis of kaliotoxin by 'one pot' native chemical ligation of three synthetic peptides. A racemic mixture of d- and l-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P1[combining macron] that diffracted to atomic-resolution (0.95 A), enabling the X-ray structure of kaliotoxin to be determined by direct methods. | |||
Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography.,Pentelute BL, Mandal K, Gates ZP, Sawaya MR, Yeates TO, Kent SB Chem Commun (Camb). 2010 Sep 28. PMID:20877851<ref>PMID:20877851</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
==See Also== | ==See Also== | ||
*[[Potassium channel toxin|Potassium channel toxin]] | *[[Potassium channel toxin|Potassium channel toxin]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
[[Category: Gates, Z P | </StructureSection> | ||
[[Category: Kent, S B.H | [[Category: Gates, Z P]] | ||
[[Category: Mandal, K | [[Category: Kent, S B.H]] | ||
[[Category: Pentelute, B L | [[Category: Mandal, K]] | ||
[[Category: Sawaya, M R | [[Category: Pentelute, B L]] | ||
[[Category: Yeates, T O | [[Category: Sawaya, M R]] | ||
[[Category: Yeates, T O]] | |||
[[Category: Chemical synthesis]] | [[Category: Chemical synthesis]] | ||
[[Category: Direct method]] | [[Category: Direct method]] | ||
[[Category: Racemic protein]] | [[Category: Racemic protein]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 08:47, 18 December 2014
X-ray structure of kaliotoxin by racemic protein crystallography
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