2ld8: Difference between revisions
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==Structure of Human Telomeric DNA in Crowded Solution== | |||
<StructureSection load='2ld8' size='340' side='right' caption='[[2ld8]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2ld8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LD8 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kf1|1kf1]], [[2jsl|2jsl]], [[2kf8|2kf8]], [[2km3|2km3]], [[2gku|2gku]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ld8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ld8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ld8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ld8 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
G-quadruplex structures formed by DNA at the human telomeres are attractive anticancer targets. Human telomeric sequences can adopt a diverse range of intramolecular G-quadruplex conformations: a parallel-stranded conformation was observed in the crystalline state, while at least four other forms were seen in K(+) solution, raising the question of which conformation is favored in crowded cellular environment. Here, we report the first NMR structure of a human telomeric G-quadruplex in crowded solution. We show that four different G-quadruplex conformations are converted to a propeller-type parallel-stranded G-quadruplex in K(+)-containing crowded solution due to water depletion. This study also reveals the formation of a new higher-order G-quadruplex structure under molecular crowding conditions. Our molecular dynamics simulations of solvent distribution provide insights at molecular level on the formation of parallel-stranded G-quadruplex in environment depleted of water. These results regarding human telomeric DNA can be extended to oncogenic promoters and other genomic G-rich sequences. | |||
Structure of Human Telomeric DNA in Crowded Solution.,Heddi B, Phan AT J Am Chem Soc. 2011 Jun 29;133(25):9824-9833. Epub 2011 Jun 6. PMID:21548653<ref>PMID:21548653</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
[[Category: Heddi, B | == References == | ||
[[Category: Phan, A T | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Heddi, B]] | |||
[[Category: Phan, A T]] | |||
[[Category: Dna]] | [[Category: Dna]] | ||
[[Category: G-quadruplex]] | [[Category: G-quadruplex]] | ||
[[Category: Molecular crowding]] | [[Category: Molecular crowding]] | ||
[[Category: Propeller-type parallel-stranded]] | [[Category: Propeller-type parallel-stranded]] | ||
Revision as of 12:12, 18 December 2014
Structure of Human Telomeric DNA in Crowded Solution
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