2kzy: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
{{STRUCTURE_2kzy|  PDB=2kzy  |  SCENE=  }}
==Solution NMR structure of the ZNF216 A20 zinc finger==
===Solution NMR structure of the ZNF216 A20 zinc finger===
<StructureSection load='2kzy' size='340' side='right' caption='[[2kzy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
{{ABSTRACT_PUBMED_021923101}}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2kzy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KZY FirstGlance]. <br>
==Function==
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[http://www.uniprot.org/uniprot/B5DF11_RAT B5DF11_RAT]] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity).
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Zfand5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kzy RCSB], [http://www.ebi.ac.uk/pdbsum/2kzy PDBsum]</span></td></tr>
==About this Structure==
</table>
[[2kzy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZY OCA].  
__TOC__
</StructureSection>
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Garner, T P.]]
[[Category: Garner, T P]]
[[Category: Layfield, R.]]
[[Category: Layfield, R]]
[[Category: Long, J E.]]
[[Category: Long, J E]]
[[Category: Searle, M S.]]
[[Category: Searle, M S]]
[[Category: A20 domain]]
[[Category: A20 domain]]
[[Category: Atrogene]]
[[Category: Atrogene]]

Revision as of 12:49, 18 December 2014

Solution NMR structure of the ZNF216 A20 zinc finger

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2kzy&oldid=2114883"